Protein Info for PS417_22330 in Pseudomonas simiae WCS417

Annotation: arginine deiminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01078: arginine deiminase
  • amino acids 10 to 416 (407 residues), 545.9 bits, E=2.6e-168
• PF02274: ADI
  • amino acids 38 to 413 (376 residues), 469.4 bits, E=8.8e-145
• PF19420: DDAH_eukar
  • amino acids 158 to 412 (255 residues), 25.1 bits, E=1e-09

Best Hits

Swiss-Prot: 82% identical to ARCA_PSEAE: Arginine deiminase (arcA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K01478, arginine deiminase [EC: 3.5.3.6] (inferred from 98% identity to pfs:PFLU4891)

Predicted SEED Role

"Arginine deiminase (EC 3.5.3.6)" in subsystem Arginine Deiminase Pathway or Arginine and Ornithine Degradation (EC 3.5.3.6)

MetaCyc Pathways

• L-arginine degradation XIII (reductive Stickland reaction) (5/5 steps found)
• L-arginine degradation V (arginine deiminase pathway) (4/4 steps found)
• L-arginine degradation XIV (oxidative Stickland reaction) (2/6 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.3.6

Sequence Analysis Tools

See A0A1N7U0V3 at UniProt or InterPro

Protein Sequence (418 amino acids)

>PS417_22330 arginine deiminase (Pseudomonas simiae WCS417)
MTTEKVKYGVHSEAGKLRKVMVCSPGLAHQRLTPNNCDELLFDDVLWVAQAKRDHFDFVT
KMRERDIDVLEMHNLLTDIVAIPEALDWILERKITANTVGLGLVDEVSSWLRSLEPRKIS
EFLIGGVSADDLPSSFGGKTIEMFRDFLGHSSFILPPLPNTQFTRDTTCWIYGGVTLNPM
YWPARRQETLLASAIYKFHPEFTNADFQIWYGDPDQEHGASTLEGGDVMPIGNGVVLIGM
GERSSHQAIGQLARNLFKNKAVEKVIVAGLPKSRAAMHLDTVFSFCDRDLVTVFPEVVNQ
IVPFTLRPDESKPHGIDIQREKTNFLETVAAALNLKALRVVETGGNSFAAEREQWDDGNN
VVAVEPGVVIGYDRNTYTNTLLRKAGVEVITISAGELGRGRGGGHCMTCPIIRDPIDY