Protein Info for PS417_22320 in Pseudomonas simiae WCS417

Annotation: amino acid APC transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 475 transmembrane" amino acids 12 to 29 (18 residues), see Phobius details amino acids 41 to 60 (20 residues), see Phobius details amino acids 94 to 120 (27 residues), see Phobius details amino acids 126 to 145 (20 residues), see Phobius details amino acids 158 to 178 (21 residues), see Phobius details amino acids 202 to 222 (21 residues), see Phobius details amino acids 234 to 256 (23 residues), see Phobius details amino acids 282 to 310 (29 residues), see Phobius details amino acids 331 to 352 (22 residues), see Phobius details amino acids 358 to 380 (23 residues), see Phobius details amino acids 395 to 413 (19 residues), see Phobius details amino acids 419 to 437 (19 residues), see Phobius details amino acids 449 to 469 (21 residues), see Phobius details TIGR00905: transporter, basic amino acid/polyamine antiporter (APA) family" amino acids 1 to 475 (475 residues), 613.2 bits, see alignment E=3.2e-188 TIGR03810: arginine-ornithine antiporter" amino acids 6 to 474 (469 residues), 718.1 bits, see alignment E=4.6e-220 PF13520: AA_permease_2" amino acids 10 to 415 (406 residues), 258.1 bits, see alignment E=1.6e-80 PF00324: AA_permease" amino acids 17 to 426 (410 residues), 65.4 bits, see alignment E=4.1e-22

Best Hits

Swiss-Prot: 74% identical to ARCD_PSEAE: Arginine/ornithine antiporter (arcD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03758, arginine:ornithine antiporter (inferred from 97% identity to pfs:PFLU4889)

Predicted SEED Role

"Arginine/ornithine antiporter ArcD" in subsystem Arginine Deiminase Pathway or Arginine and Ornithine Degradation or Polyamine Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UK21 at UniProt or InterPro

Protein Sequence (475 amino acids)

>PS417_22320 amino acid APC transporter (Pseudomonas simiae WCS417)
MSQPAQKLRLSALIALVVGSMIGGGIFSLPQNMAARAEVGAVLIGWAITAVGMLTLAFVF
QTLANRKPELDSGVYAYAKAGFGDYMGFSSAWGYWISAWMGNVGYFVLLFSTLGYFFPIF
GQGNTPVAIGCASLLLWAVHFLVLRGIKEAAFINQITTVAKIVPLLMFIVIAGVAFKAEI
FTRDIWGVGNPNMGNVVDQVRNMMLVTVFVFIGIEGASVYSARAEKRSDVGRATVIGFLG
VLALLVLVNVLSLGIMSQPQLAQLQNPSLAGVLEHIVGPWGAMAISIGLAVSLLGALLSW
ALLCAEILYATAHDKTMPAFLKKENANQVPVNALWLTNVMIQVFLVITLFSHSTYTTLIY
LASSMILVPYLWSAAYAVLLSGRGETYQGAHGQRIKDLLVGLIALGYAVWLLYAGGLKYL
LLSALLYAPGVILFALAKREQDQPLFTHVEKGIFSCVIAGAGLAAYGLYSGVLSL