Protein Info for GFF4336 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: 2-dehydropantoate 2-reductase (EC 1.1.1.169)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00745: 2-dehydropantoate 2-reductase
  • amino acids 15 to 260 (246 residues), 214.7 bits, E=9.3e-68
• PF02558: ApbA
  • amino acids 25 to 112 (88 residues), 61.7 bits, E=6.2e-21
• PF08546: ApbA_C
  • amino acids 137 to 258 (122 residues), 128.4 bits, E=2.1e-41

Best Hits

Swiss-Prot: 100% identical to PANE_SALTY: 2-dehydropantoate 2-reductase (panE) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K00077, 2-dehydropantoate 2-reductase [EC: 1.1.1.169] (inferred from 98% identity to ses:SARI_02500)

MetaCyc: 87% identical to 2-dehydropantoate 2-reductase (Escherichia coli K-12 substr. MG1655)
2-dehydropantoate 2-reductase. [EC: 1.1.1.169]

Predicted SEED Role

"2-dehydropantoate 2-reductase (EC 1.1.1.169)" in subsystem Coenzyme A Biosynthesis (EC 1.1.1.169)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
• phosphopantothenate biosynthesis I (4/4 steps found)
• phosphopantothenate biosynthesis III (archaea) (2/4 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (5/10 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.169

Use Curated BLAST to search for 1.1.1.169

Protein Sequence (272 amino acids)

>GFF4336 2-dehydropantoate 2-reductase (EC 1.1.1.169) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
VPQPYCSVNLIDTDGSFFNESLTANDPDFLAKSELLLVTLKAWQVSDAVRTLASTLPVTS
PILLIHNGMGTIEELQNIQQPMLMGTITHAARRDGNIIIHVANGTTHIGPAREQDGDYSY
LADILQGVLPDVAWHNNIRAEMWRKLAVNCVINPLTALWNCPNGELRHHTDEINAICEEV
AAVIEREGYHTSADDLRYYVEQVIDSTAENISSMLQDVRAMRHTEIDYITGYLLKRARVH
GLAVPENSRLFEMVKRKESEYERSGTGMPRPW