Protein Info for GFF4317 in Xanthobacter sp. DMC5

Annotation: Dihydroorotate dehydrogenase (quinone)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 356 TIGR01036: dihydroorotate dehydrogenase (fumarate)" amino acids 4 to 356 (353 residues), 402.3 bits, see alignment E=7.5e-125 PF01180: DHO_dh" amino acids 43 to 339 (297 residues), 276.4 bits, see alignment E=1.3e-86

Best Hits

Swiss-Prot: 81% identical to PYRD_XANP2: Dihydroorotate dehydrogenase (quinone) (pyrD) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

KEGG orthology group: K00226, dihydroorotate dehydrogenase (fumarate) [EC: 1.3.98.1] (inferred from 81% identity to xau:Xaut_0056)

Predicted SEED Role

"Dihydroorotate dehydrogenase (EC 1.3.3.1)" in subsystem De Novo Pyrimidine Synthesis (EC 1.3.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.1 or 1.3.98.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (356 amino acids)

>GFF4317 Dihydroorotate dehydrogenase (quinone) (Xanthobacter sp. DMC5)
MDLYALVRPFLGLVTPERAHGYAVRALAKGLMPDLSGHDDPVLATRVWGLDFPNPVGLAA
GFDKHCEVADGLLKMGFGFAEMGTVTPRPQPGNPQPRLFRLEEDEAVINRFGFNSEGLAP
FVYRLAKRRSAGGKGILGANVGKNKESEDTLEDYAAGVSATCRLADYIVCNISSPNTPGL
RALQARAEMEALLAHLVGVRNASVPDPAERPPLLVKVAPDLDDAGLADVAEVALETGIDG
IIMGNTTLSRPASLHSAHKGEAGGLSGKPLMTLSTERLGALYRLVGGRLPLVGSGGISSG
ADAYAKIRAGASLVQLYSALVFHGPGLVGRIKTDLAARLKADGFAHVSDAVGADVR