Protein Info for GFF4266 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Propionate--CoA ligase (EC 6.2.1.17)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02316: propionate--CoA ligase
  • amino acids 1 to 628 (628 residues), 1239.2 bits, E=0
• PF16177: ACAS_N
  • amino acids 4 to 57 (54 residues), 83.3 bits, 1.2e-27
• PF00501: AMP-binding
  • amino acids 59 to 445 (387 residues), 247.4 bits, E=3.5e-77
• PF13193: AMP-binding_C
  • amino acids 509 to 592 (84 residues), 78.8 bits, E=7.4e-26

Best Hits

Swiss-Prot: 100% identical to PRPE_SALTY: Propionate--CoA ligase (prpE) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01908, propionyl-CoA synthetase [EC: 6.2.1.17] (inferred from 92% identity to cro:ROD_03971)

MetaCyc: 100% identical to propionate-CoA ligase (Salmonella enterica enterica serovar Typhimurium)
Propionate--CoA ligase. [EC: 6.2.1.17]

Predicted SEED Role

"Propionate--CoA ligase (EC 6.2.1.17)" in subsystem Methylcitrate cycle or Propionate-CoA to Succinate Module (EC 6.2.1.17)

MetaCyc Pathways

• 2-methylcitrate cycle I (5/5 steps found)
• acrylate degradation II (2/3 steps found)
• 2-methylcitrate cycle II (4/6 steps found)
• L-isoleucine biosynthesis IV (4/6 steps found)
• superpathway of coenzyme A biosynthesis II (plants) (5/10 steps found)
• β-alanine biosynthesis II (1/6 steps found)

KEGG Metabolic Maps

• Propanoate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.17

Protein Sequence (628 amino acids)

>GFF4266 Propionate--CoA ligase (EC 6.2.1.17) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MSFSEFYQRSINEPEAFWAEQARRIDWRQPFTQTLDHSRPPFARWFCGGTTNLCHNAVDR
WRDKQPEALALIAVSSETDEERTFTFSQLHDEVNIVAAMLLSLGVQRGDRVLVYMPMIAE
AQITLLACARIGAIHSVVFGGFASHSVAARIDDARPALIVSADAGARGGKILPYKKLLDD
AIAQAQHQPKHVLLVDRGLAKMAWVDGRDLDFATLRQQHLGASVPVAWLESNETSCILYT
SGTTGKPKGVQRDVGGYAVALATSMDTIFGGKAGGVFFCASDIGWVVGHSYIVYAPLLAG
MATIVYEGLPTYPDCGVWWKIVEKYQVNRMFSAPTAIRVLKKFPTAQIRNHDLSSLEALY
LAGEPLDEPTASWVTETLGVPVIDNYWQTESGWPIMALARALDDRPSRLGSPGVPMYGYN
VQLLNEVTGEPCGINEKGMLVIEGPLPPGCIQTIWGDDARFVKTYWSLFNRQVYATFDWG
IRDAEGYYFILGRTDDVINIAGHRLGTREIEESISSYPNVAEVAVVGIKDALKGQVAVAF
VIPKQSDTLADREAARDEENAIMALVDNQIGHFGRPAHVWFVSQLPKTRSGKMLRRTIQA
ICEGRDPGDLTTIDDPASLQQIRQAIEE