Protein Info for GFF4224 in Variovorax sp. SCN45

Annotation: Transcriptional regulator, AcrR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 210 PF00440: TetR_N" amino acids 26 to 67 (42 residues), 45.1 bits, see alignment 1e-15 PF16925: TetR_C_13" amino acids 94 to 202 (109 residues), 102.9 bits, see alignment E=2e-33 PF21993: TetR_C_13_2" amino acids 94 to 198 (105 residues), 59.4 bits, see alignment E=5.3e-20

Best Hits

Swiss-Prot: 52% identical to ACUR_RHOS4: Transcriptional regulator AcuR (acuR) from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

KEGG orthology group: None (inferred from 62% identity to bgl:bglu_1g16500)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (210 amino acids)

>GFF4224 Transcriptional regulator, AcrR family (Variovorax sp. SCN45)
MTQTKEVSGARARKAQAYASAREVLLRCGMELLTEQGFSATGLEAVLKRATVPKGSFYYY
FASKEAFGREVMDAYDAYFGKKLDRWLQDGSRAPLDRLMDFVADASAGMRKHEFRRGCLV
GNLSQELGALPEAYRARLDAIFTGWQRKVAACLREAQLSGAVPAGLDCDQLAEFFWIAWE
GAVLRARLLRNDQPLRNFIATFLVALGVRA