Protein Info for GFF4218 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Dihydropteroate synthase (EC 2.5.1.15)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01496: dihydropteroate synthase
  • amino acids 36 to 291 (256 residues), 306.7 bits, E=7.5e-96
• PF00809: Pterin_bind
  • amino acids 37 to 277 (241 residues), 257.3 bits, E=8e-81

Best Hits

Swiss-Prot: 51% identical to DHPS_NEIMB: Dihydropteroate synthase (folP) from Neisseria meningitidis serogroup B (strain MC58)

KEGG orthology group: K00796, dihydropteroate synthase [EC: 2.5.1.15] (inferred from 73% identity to dia:Dtpsy_1476)

MetaCyc: 48% identical to dihydropteroate synthase (Escherichia coli K-12 substr. MG1655)
Dihydropteroate synthase. [EC: 2.5.1.15]

Predicted SEED Role

"Dihydropteroate synthase (EC 2.5.1.15)" in subsystem Folate Biosynthesis (EC 2.5.1.15)

MetaCyc Pathways

• superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
• superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
• tetrahydrofolate biosynthesis I (3/3 steps found)
• superpathway of chorismate metabolism (43/59 steps found)
• tetrahydrofolate biosynthesis II (2/3 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Folate biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.15

Protein Sequence (295 amino acids)

>GFF4218 Dihydropteroate synthase (EC 2.5.1.15) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MHTRGFGPVVVSTALSPSPMRWQTTRFDIDLTRPRVMGIVNVTPDSFSDGGLHAGTAAAL
KHCEQLLKEGADILDIGGESTRPGSPAVPLDEELARVLPVVREAVRLDVPISVDTYKPEV
MRAVLDAGADIVNDIWALRRGDALQVVASHPRCGVCLMHMHRDPQTMQVAPMDGDVLPDV
IAFLAERAGALTALGVARERIVLDPGVGFGKTVAQNLSLLARQAELLPLGFDVLAGWSRK
STLGAVTRHERPADRAAASVAAALLAVERGARVVRVHDVRDTVDAIKVWLALQTG