Protein Info for GFF4209 in Sphingobium sp. HT1-2

Annotation: Nicotinamide-nucleotide adenylyltransferase, NadM family (EC 2.7.7.1) / ADP-ribose pyrophosphatase (EC 3.6.1.13)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.

Predicted SEED Role

"Nicotinamide-nucleotide adenylyltransferase, NadM family (EC 2.7.7.1) / ADP-ribose pyrophosphatase (EC 3.6.1.13)" in subsystem NAD and NADP cofactor biosynthesis global or Nudix proteins (nucleoside triphosphate hydrolases) or NAD regulation (EC 2.7.7.1, EC 3.6.1.13)

MetaCyc Pathways

• NAD biosynthesis from nicotinamide (1/2 steps found)
• NAD salvage pathway IV (from nicotinamide riboside) (1/2 steps found)
• superpathway of NAD biosynthesis in eukaryotes (7/14 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.1, 3.6.1.13

Use Curated BLAST to search for 2.7.7.1 or 3.6.1.13

Protein Sequence (227 amino acids)

>GFF4209 Nicotinamide-nucleotide adenylyltransferase, NadM family (EC 2.7.7.1) / ADP-ribose pyrophosphatase (EC 3.6.1.13) (Sphingobium sp. HT1-2)
MAEGRLIVAPLDDPLYSATARVADVQRKMRAIVPDHGNHHGFQNRGTADFRVALTVYGKD
SSSYYLKLFPEWENIQVDSQYGTFSSTDVRRRYFQRILEIADTILSLGVADFLRSFVMSE
ICRSLLEEAEYLDVYPTQWGVGPLTTADALVVQSGHILLVECGQAPGKGLLALPGGFVNP
AERIRDAAFGNCARKPQSATAYAHRGSREASGRCRSPDIGRSNCALR