Protein Info for PS417_21535 in Pseudomonas simiae WCS417

Annotation: chemotaxis protein CheY

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 241 PF00072: Response_reg" amino acids 8 to 117 (110 residues), 87.3 bits, see alignment E=8.2e-29 PF00486: Trans_reg_C" amino acids 157 to 231 (75 residues), 81.5 bits, see alignment E=3.9e-27

Best Hits

Swiss-Prot: 35% identical to PRRA_MYCLE: Transcriptional regulatory protein PrrA (prrA) from Mycobacterium leprae (strain TN)

KEGG orthology group: K07661, two-component system, OmpR family, response regulator RstA (inferred from 96% identity to pfs:PFLU4724)

Predicted SEED Role

"Transcriptional regulatory protein RstA" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UJN4 at UniProt or InterPro

Protein Sequence (241 amino acids)

>PS417_21535 chemotaxis protein CheY (Pseudomonas simiae WCS417)
MEQEAWQVLIVEDDQRLAELTREYLESNGLQVSVEGDGALAAARIIAEQPDLVILDLMLP
GEDGLSICRKVRQRYDGVILMLTARTDDMDQVLGLDMGADDYVCKPVRPRLLLARIQALL
RRSEPTEPVAVENQRRLQFGPLVVDNALREAWLNNDGIELTSAEFDLLWLLVANAGRILS
REELFIALRGIGYDGQDRSIDVRISRIRPKIGDDPIHPRLIKTIRSKGYLFVPEAAADMP
L