Protein Info for GFF4204 in Xanthobacter sp. DMC5

Annotation: Alpha-2-macroglobulin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1700 1776 signal peptide" amino acids 1 to 45 (45 residues), see Phobius details PF21142: A2M_bMG2" amino acids 327 to 427 (101 residues), 29.8 bits, see alignment 2.2e-10 PF11974: bMG3" amino acids 451 to 552 (102 residues), 100 bits, see alignment 3.2e-32 PF01835: MG2" amino acids 558 to 653 (96 residues), 77.9 bits, see alignment 2.8e-25 PF17972: bMG5" amino acids 659 to 785 (127 residues), 106.6 bits, see alignment 5.2e-34 PF17962: bMG6" amino acids 791 to 900 (110 residues), 97.4 bits, see alignment 2.7e-31 PF07703: A2M_BRD" amino acids 912 to 1056 (145 residues), 72.5 bits, see alignment E=2e-23 PF00207: A2M" amino acids 1124 to 1196 (73 residues), 23.6 bits, see alignment (E = 1.7e-08) PF07678: TED_complement" amino acids 1315 to 1406 (92 residues), 28.8 bits, see alignment 3e-10 PF17973: bMG10" amino acids 1633 to 1760 (128 residues), 87 bits, see alignment 5.7e-28

Best Hits

KEGG orthology group: K06894, (no description) (inferred from 52% identity to bbt:BBta_3915)

Predicted SEED Role

"Alpha-2-macroglobulin"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1776 amino acids)

>GFF4204 Alpha-2-macroglobulin (Xanthobacter sp. DMC5)
MDLRRRLLTIRRNRAPLSTRFGLALALMASALMAGAVPGTPAFAQQARPQAPAAQPAPVQ
PAAPLPPRAASQKTFQRQDLIAGARRYERLLRREATAPTGPLDKARRDAAQAFQRNDARA
AAELYAGLALVQAQDPGIWMRLARSLAAIKPTDDEDASTFIDNALAAAFIAYRRATTRAE
EGEALSFIGHIYADRRLWQPAIDTMKLALELRDTPADRSFYDKLKEEHGFRLVDYSVESD
ATSPRACVQFSDDIAPGTDFAAFVQVGGMDKPAITGEARQICVEGLKHGSRYTIAVRPGV
PAANGEKLKKATELSIYVRDRQPSAHFSGRNYVLPRTGQKGIPVTSVNSRELKIKVLRIG
DRGLVPTAIQGEFRQGLDGYVRQRLAEGAGIEVFSGTLEVDGALNADVVTAIPVNEAVGK
LEAGVYAMTAEPRETSGDDDYGSLATQWFIVSDLGMTALAAPDGVHVLVRSLGSAEPVAG
ADVTLVARSNEILGTAKTDASGYARFDAGLSRGPAGMGPEVVTARGANGDYAFLSMKENA
FDLTDRGVSGREAPGALDAFLATERGVYRSGETVHVTVLLRDAAGNAAPNVPLTVQLVRP
DGVADRRVVVQDQGAGGRTLDLPILKGAMTGTWRAKALTDLKAPSIGEVTFLVEDYVPDR
VEFDLSSREPRLPRDKAVEVLVDGRFLFGAPASGLDVEAETELRAAANRPGFAGYAFGNA
QDEVLAERQPTADAPVTDARGRATIRLLAGQLPKTARPLEMEAFVRLVEAGGRAVQRTIV
LPLAPAGSQIGVKPLFADRVREGETANFDVVVAGVDDKLLASPGLTWKLSRIETRYQWYR
VSGSWDYEPVKTVTRVGEGVIATAADGPARLSVPTQYGRYRLDLTGDGLPLTSVTFEAGF
GGDGNADTPDRLELTLDKQAYAAGDTLEATLTARTAGTATVMVVNDGVRDAKVLQVQPGA
SKVSFKVDGGWGPGAYVVAFLHRPLDVQASRMPGRAMGLSWFSVDKEARTLKVELSPPAE
MRPNTTLAIPVKVSNLPAGEKAYVTVAAVDVGILNLTGYKPPAPDAVVFGQRRLAADIRD
FYGALIDGMQGAAGRLRSGGDGGETAMMASPPQGPPVALFSGLVEVGADGTATVSFPVPA
FDGTLRVMAIAWSQNRLGHAAADVVVRDKVVMLATLPRFLASGDRSSFNLDLTNVEGPAG
DYRLEVTATGAAAVTGTVPPLTLAQKQRQSVRLALEGRGVGPATLTARLTGQGIDITRSF
QMQVRPAYPDIERRTVRNLAPGEIISVSRDLLADLLPGTGGVAVSVSPSSAIDVPALLAA
LDRYPYGCTEQVTSRALPLLSYNELSVLVGRAKDPEADQRIRDAIVRVFSRQGSDGSFGL
WSAGGNDTWLDAYVVDFLTRAKEKGFAVPDQAFSLALDRLRNVVNLAGADMRSASEGLAY
ALYVLARNGRAPLGDLRYIADTRLKDLASPLARGQVGAALALLGDRTRAERAFNVALEGI
PASATAPEIGRSDFGSVLRDAAALTVLAREAGLDKVAAVALARVDAARVRTERTSTQENA
WMLLAARTLAASAANMTLEVDGGLVRGPFGSKLSRADLERGPLTLRNAGTEAVKVVVGVN
GAPVAPEPPISKGFSLDRKYFTLDGKPADPTKAVQNQRFAVVLTFSEEKSALADVLLVDF
LPAGFEIENPNLIKGGDGGFTWLDETSEAGHVEFRDDRFVASVTREEGDAPFVVAYTVRA
VSPGRYAHPPAMVEDMYRPDRFARTAAGSMEVAPAR