Protein Info for GFF4192 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: DNA-binding protein HU-alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 75 90 PF00216: Bac_DNA_binding" amino acids 1 to 90 (90 residues), 117 bits, see alignment E=3.5e-38 PF18291: HU-HIG" amino acids 2 to 89 (88 residues), 30.3 bits, see alignment E=3.9e-11

Best Hits

Swiss-Prot: 100% identical to DBHA_SALTI: DNA-binding protein HU-alpha (hupA) from Salmonella typhi

KEGG orthology group: K05787, DNA-binding protein HU-alpha (inferred from 99% identity to ecd:ECDH10B_4189)

Predicted SEED Role

"DNA-binding protein HU-alpha" in subsystem DNA structural proteins, bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (90 amino acids)

>GFF4192 DNA-binding protein HU-alpha (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MNKTQLIDVIADKAELSKTQAKAALESTLAAITESLKEGDAVQLVGFGTFKVNHRAERTG
RNPQTGKEIKIAAANVPAFVSGKALKDAVK