Protein Info for GFF4191 in Sphingobium sp. HT1-2

Annotation: DNA mismatch repair protein MutS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 880 PF01624: MutS_I" amino acids 12 to 128 (117 residues), 134.3 bits, see alignment E=5.5e-43 TIGR01070: DNA mismatch repair protein MutS" amino acids 12 to 872 (861 residues), 810.6 bits, see alignment E=9.2e-248 PF05188: MutS_II" amino acids 137 to 249 (113 residues), 54.5 bits, see alignment E=4.4e-18 PF05192: MutS_III" amino acids 273 to 568 (296 residues), 141.7 bits, see alignment E=9.8e-45 PF05190: MutS_IV" amino acids 434 to 525 (92 residues), 63.7 bits, see alignment E=4e-21 PF00488: MutS_V" amino acids 626 to 813 (188 residues), 267.9 bits, see alignment E=1.4e-83

Best Hits

KEGG orthology group: K03555, DNA mismatch repair protein MutS (inferred from 88% identity to sjp:SJA_C1-35010)

Predicted SEED Role

"DNA mismatch repair protein MutS" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (880 amino acids)

>GFF4191 DNA mismatch repair protein MutS (Sphingobium sp. HT1-2)
MANSTSTTTQPTPMMAQYFTLKAEAQDCLLFYRMGDFFELFFDDAKMAAATLDIALTSRG
EHAGQPIPMCGVPVHSAESYLARLIKGGHRVAIAEQTETPAEAKARGGKALVARAIVRYV
TAGTLTEETLLDSRRDNMLVALAQTGGEGELGLAAADISTGRFETMTVRAGDLPAELARL
RPSEVVIAEGSTLEVANSHPFDKAAFSSARAEEALKRLFAVATLDGFGQFSRAELAAMGG
LISYLDHAGKGTMPFLAPPLRKTSGAHVAIDAATRESLEIVATTGGTRAGSLLGAVDRTV
TGAGARLLAQDLSAPLMDAPLIDARLGLVQLFHDDATLRSQLRAALRALPDIGRALGRVA
VGRGSPRDLGQLRDGLGEARLLRERLGRLADQPLLLTQLLPALDGHGALVDALARALVPS
PPTETNNGGYIADGFDPALDELRRLAGDGRRAIAALEAQYREQTGISALKIRHNGVLGYH
VEVPARAADQLMQPESGFTHRQTLAGIVRFNSIDLHEQAGRVAQAGAHALVAEAAHLETL
IDAVLDRKADIARAADALARLDVAAALAERAAEGGWQRPLFVVEDGVGPCLDIVGGRHPV
VEDALRAQGQPFVANDCRLVATDRLWLVTGPNMGGKSTFLRQNALIVILAQAGAFVPAET
ATLTLVDRLFSRVGASDNLARGRSTFMVEMVETAAILAQATEHSFVILDEVGRGTSTYDG
LALAWAVVEAVHEVNRCRCLFATHHHELTRLSETLDALSLHHVRAREWKGDLVLLHELAE
GPADRSYGLAVARLAGLPPLVLKRAKDVLGRLEAGKAKTGGIAAGLDDLPLFASVATQAE
EVADPLRDALDGIDADALSPREALDHIYRLKQLAAASHHE