Protein Info for GFF4179 in Sphingobium sp. HT1-2

Annotation: Phosphomannomutase (EC 5.4.2.8)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 460 PF02878: PGM_PMM_I" amino acids 10 to 130 (121 residues), 102.5 bits, see alignment E=3.3e-33 PF02879: PGM_PMM_II" amino acids 154 to 250 (97 residues), 71.8 bits, see alignment E=1.3e-23 PF02880: PGM_PMM_III" amino acids 254 to 361 (108 residues), 77.1 bits, see alignment E=2.5e-25 PF00408: PGM_PMM_IV" amino acids 370 to 444 (75 residues), 45.9 bits, see alignment E=9.5e-16

Best Hits

Swiss-Prot: 56% identical to EXOC_AZOBR: Phosphomannomutase (exoC) from Azospirillum brasilense

KEGG orthology group: None (inferred from 73% identity to sch:Sphch_2218)

Predicted SEED Role

"Phosphomannomutase (EC 5.4.2.8)" in subsystem Alginate metabolism or Mannose Metabolism (EC 5.4.2.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.8

Use Curated BLAST to search for 5.4.2.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (460 amino acids)

>GFF4179 Phosphomannomutase (EC 5.4.2.8) (Sphingobium sp. HT1-2)
MAHRFHPTLLREYDMRGVVGPMLGEADGYALGRSFATWVRRAGGSAVAVGYDGRLSSPML
EGALVHGLTDSGVDVLRVGLGPTPMLYYAEAEMDVAGAIQVTGSHNPADQNGFKLVLDHA
PFHGEAIQQLGAMAAAGDWLAGEGRVRDVDIMPAYVERLVRDFDGAAWRIGWDAGNGAAG
PVVEKLVQLLPGEHHLLFTDVDGNFPNHHPDPTEEANLADLRSLVLSRKLDFGVAFDGDG
DRIGVVDGLGRIIWGDQLLGLFAQVVLKDRPGAPIVADVKASQALFDEIARLGGEPVLWK
TGHSHIKSKMKQIGSPLGGEMTGHIMFADDFYGFDDGLYAAVRLIRAAARLRRTVTDLRG
DMAEMVNTPEIRVAVPEDRKFAIIDELRDRLIASGAIVESIDGARVRTVDGWWLLRASNT
QNALTARAEASDVAGLARLLAEIESHLRDSGVDQRLQAAK