Protein Info for GFF4152 in Xanthobacter sp. DMC5

Annotation: Multidrug resistance protein MdtE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 410 signal peptide" amino acids 1 to 41 (41 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 55 to 375 (321 residues), 216.6 bits, see alignment E=2.1e-68 PF16576: HlyD_D23" amino acids 78 to 293 (216 residues), 47.8 bits, see alignment E=1.7e-16 PF13533: Biotin_lipoyl_2" amino acids 83 to 126 (44 residues), 28.6 bits, see alignment 1.4e-10 PF13437: HlyD_3" amino acids 195 to 284 (90 residues), 40.3 bits, see alignment E=7.3e-14

Best Hits

KEGG orthology group: None (inferred from 77% identity to xau:Xaut_2826)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (410 amino acids)

>GFF4152 Multidrug resistance protein MdtE (Xanthobacter sp. DMC5)
MPRLDVPIRTGRRLKGLAALLLAGSAMLLAGCGQENPANAGEAPASKEATLARPVQVTTV
SFRPRQTQKSFVGVVRARREIDLAFRVGGKVVQRLVEVGDRIEPGTVVARLDKEDLKLEL
ESAKAEMQAATANLAQTTTEDTRYRALTAKGAASNADLDRKSLAKEEAVGRLERAKRSLE
LAENRLSYADLVTDAAGVVVATSAEPGQVVASGQTIVRVARLDEKEALVSLPETALADAR
TADAVVTLWADPGRRIPAHLRELSPQADVTSRTYPARFSLEGADGTVALGMTATVTLRPK
DQQQVARLPLSALIDRGHGPQVFVVDGATHAIVARPVEIAAYTGDEVLLSGGVAPGDAVV
ILGVQTLLPGQKVRTVQAPAVTEVAERLPSVETRRAQAPAAGTSVAEQRP