Protein Info for GFF4151 in Xanthobacter sp. DMC5

Annotation: Nickel and cobalt resistance protein CnrA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1049 transmembrane" amino acids 34 to 53 (20 residues), see Phobius details amino acids 357 to 376 (20 residues), see Phobius details amino acids 383 to 403 (21 residues), see Phobius details amino acids 409 to 433 (25 residues), see Phobius details amino acids 447 to 472 (26 residues), see Phobius details amino acids 485 to 508 (24 residues), see Phobius details amino acids 545 to 565 (21 residues), see Phobius details amino acids 877 to 896 (20 residues), see Phobius details amino acids 904 to 925 (22 residues), see Phobius details amino acids 931 to 952 (22 residues), see Phobius details amino acids 979 to 1000 (22 residues), see Phobius details amino acids 1006 to 1027 (22 residues), see Phobius details PF00873: ACR_tran" amino acids 27 to 1027 (1001 residues), 547.1 bits, see alignment E=3.9e-168

Best Hits

KEGG orthology group: None (inferred from 90% identity to xau:Xaut_2827)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1049 amino acids)

>GFF4151 Nickel and cobalt resistance protein CnrA (Xanthobacter sp. DMC5)
VSAAGPSHDPASGSGSEPEGPSRFNLSRWAITHRALTLFAILLLGAAGAYSYFNLGRAED
PSFTIKVMVVQAAWPGATASEMQAQVADPIEKKLQSLPHLDRVESYSRPGVSFVQVFLRD
NTPAKEVKDLWYQVRKKVSDVRGDLPAGVIGPGFDDEYGDVYSALYILSGQGAAPAELKR
QAELIRQRLLRVPNVEKVDLIGERPEKIYIEFSHARLANLGITPQQVFDSVARQNAVVAG
GAVDTRSDRINLRVTGAFTGVEAIAEVPVAVNGALLRLGDIATVKRGYEDPPAFLMRQHG
LPALGIGVSMAQGANILTLGEGLKTAMAEATAELPHGIDVTQVADQPHIVGESVGEFLKT
FLEALVIVLVVSFLSLGFRTGIVVALSVPLVLAIVFLIMFSAGMDLHRITLGALIIALGL
LVDDAIIAIEMMVVKMEEGWDRMSAATFAWTSTAFPMLTGTLVTAAGFLPVGFAKSSSGE
YAGGIFWVVGIALIASWFVAVIFTPYLGTVLLPDMKKAGGHHEMHDGRLYRMLRGTLEFC
LRHRFMVIGTTVVMFAGSVVAFGFVQQQFFPTSTRPELFLEIRLPEGTSITVTEATAKKA
EALVGEDPDVATSTTYVGRGAPRFWLGLNPVLPNPNFAQIVIVAKDVAARERLKARLDAE
LAEGALSEARVRVDRFVFGPPVGFPVQFRVVGPDPIAVRDIAEKVRLVMASDTDMIDPHL
NWGEQVKSITLTVDQDRARALGTSPRDIAETLQTLLQGYAITQLREGNLLIDVMARAVPE
ERVDLEHLAALTVTTRNGLAVPLGQVARIGYAHEEPILWRRDRDLVLTVRGDVRDGVQPP
DVTTRLLPKLAQLKAELPPGYRIETGGSIEESAKANASLAAVFPVMIIVMLTLLMIQLQS
FSRLALVLATAPLGLIGAAAALLIAHRPFGFVALLGLIALAGMIMRNTVILVDQIDHDIR
DGATPHRAIVEATLRRARPVVLTALAAVLGMIPLAESVFWGPMAVTIMGGLLVATVLTLL
VVPALYATWFRVKVTEEETAPAALPQPAS