Protein Info for GFF4144 in Variovorax sp. SCN45

Annotation: Prolyl endopeptidase (EC 3.4.21.26)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 130 PF22658: YycE-like_N" amino acids 5 to 56 (52 residues), 67.1 bits, see alignment E=1.5e-22 PF00903: Glyoxalase" amino acids 6 to 121 (116 residues), 39.1 bits, see alignment E=1.4e-13 PF22659: YycE-like_C" amino acids 70 to 123 (54 residues), 79.2 bits, see alignment E=2.8e-26

Best Hits

Swiss-Prot: 38% identical to YYCE_BACSU: Uncharacterized protein YycE (yycE) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 59% identity to rcu:RCOM_1933770)

Predicted SEED Role

"Prolyl endopeptidase (EC 3.4.21.26)" (EC 3.4.21.26)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.26

Use Curated BLAST to search for 3.4.21.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (130 amino acids)

>GFF4144 Prolyl endopeptidase (EC 3.4.21.26) (Variovorax sp. SCN45)
MTIQLRIARPVSSFERSLAMYRDGLGLRELERFVDHQGFDAAILGFPGLPYHFAFTHCRE
HPIVPAPTVDDLAVFYVPDLVEWQRLCNNMLAAGFAEVSSFNPYWQRRGRTFADPDGYRV
VLQQAAWGGS