Protein Info for GFF4138 in Xanthobacter sp. DMC5

Annotation: Peptide methionine sulfoxide reductase MsrB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00357: methionine-R-sulfoxide reductase
  • amino acids 16 to 137 (122 residues), 182.5 bits, E=1.8e-58
• PF01641: SelR
  • amino acids 25 to 138 (114 residues), 174.2 bits, E=4.2e-56

Best Hits

Swiss-Prot: 63% identical to MSRB_THEEB: Peptide methionine sulfoxide reductase MsrB (msrB) from Thermosynechococcus elongatus (strain BP-1)

KEGG orthology group: K07305, peptide-methionine (R)-S-oxide reductase [EC: 1.8.4.12] (inferred from 81% identity to xau:Xaut_2840)

MetaCyc: 56% identical to methionine sulfoxide reductase B (Escherichia coli K-12 substr. MG1655)
L-methionine (R)-S-oxide reductase. [EC: 1.8.4.14]; Peptide-methionine (R)-S-oxide reductase. [EC: 1.8.4.14, 1.8.4.12]

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)" (EC 1.8.4.12)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.4.12 or 1.8.4.14

Protein Sequence (147 amino acids)

>GFF4138 Peptide methionine sulfoxide reductase MsrB (Xanthobacter sp. DMC5)
MSTSAPSDADHTKVVKSESEWRSCLTPEQFRITRQAGTERAFTGPYWDEKRAGLYECVAC
GAPLFRSETKYNSGTGWPSFFQPVSPEAVVTHEDVSHGMRRIEVRCASCDSHLGHVFPDG
PAPTGLRFCMNGTALSLKTDDGADRGV