Protein Info for PS417_20925 in Pseudomonas simiae WCS417

Annotation: nucleotide cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 799 transmembrane" amino acids 20 to 42 (23 residues), see Phobius details amino acids 317 to 337 (21 residues), see Phobius details PF03924: CHASE" amino acids 88 to 272 (185 residues), 114.1 bits, see alignment E=2.6e-36 PF00989: PAS" amino acids 367 to 491 (125 residues), 34 bits, see alignment E=8.8e-12 TIGR00229: PAS domain S-box protein" amino acids 376 to 503 (128 residues), 36.3 bits, see alignment E=5.4e-13 PF08448: PAS_4" amino acids 376 to 498 (123 residues), 24.2 bits, see alignment E=1.2e-08 PF13426: PAS_9" amino acids 379 to 495 (117 residues), 27.6 bits, see alignment E=1e-09 PF08447: PAS_3" amino acids 534 to 607 (74 residues), 36 bits, see alignment E=2.4e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 635 to 794 (160 residues), 151 bits, see alignment E=2.6e-48 PF00990: GGDEF" amino acids 639 to 791 (153 residues), 140.2 bits, see alignment E=1.9e-44

Best Hits

KEGG orthology group: None (inferred from 93% identity to pfs:PFLU4600)

Predicted SEED Role

"CHASE domain/PAS domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UJC0 at UniProt or InterPro

Protein Sequence (799 amino acids)

>PS417_20925 nucleotide cyclase (Pseudomonas simiae WCS417)
MPLQAVRPKILGFISEQASAWLVAIVVLLAGFTLTAIVAWAASDLYQQQVRQRFQLLVNE
RYTRLQERFEDQEQRLNSLRRFFVNSDTVSREEFDGFAQPLLLRARAYSWAPRVYREQRS
QFEQDVSSQLGTPFVIRELNSAGELAPAPERDEYVPVLYSQTQSLLGAPFGFDLLAQPLR
RSTLERAQKTGRLAVSQPMQLVGVEPVYATGVLLVAPVSHLGTSDQSQHEPFGYVMAVIS
IRQLVADGLPKPDRDNLVMQIIDTSDLQKRVLFESSNVVGDSDLVGARRLTLGDHVYALN
LRPSQVFDHANHSSLNTILFMGGLLSLLLSALLYVLVSQRQRALKLVEQRTAQLRLREQE
LRGAHGQLRSVLNAATQVAIIATDLRGVINTFNAGAEQMLGFKAEQVVGTHTLESLHVAA
ELEARSASLSMALGKRIPASQAMLVESPDNLHEAHEWTLIREDGSQLTVNMLATVLLDDH
GLWIGHLAIYLDITEQKRAYEALAARDRLLKKLSAHVPGGIFQFTLEPQDNWKFIYASDG
MRDIYEIEPNILQQDAKRVIERIHPLDAERVRASIRLSALQLSHWREEYRVVLPQRGLRW
IRGEATPEELPAGGTLWHGYVSDISDLKRVEEELRALSITDSLTGIHNRRYFQDRLKAEM
VRLNRTSGNLSVIMLDIDHFKRINDQHGHAVGDGVLQELCRRISQRLRRTDVFCRLGGEE
FMVLCPHTDGEQAYSLAMELWASLRGAPMDPVGIVTASFGVASWRVDEGIDGLLLRADSA
VYVAKQAGRDRVEAERLRA