Protein Info for GFF4082 in Sphingobium sp. HT1-2

Annotation: Glutathione peroxidase (EC 1.11.1.9) @ Thioredoxin peroxidase (EC 1.11.1.15)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00255: GSHPx
  • amino acids 8 to 110 (103 residues), 125.4 bits, E=3.7e-41

Best Hits

Swiss-Prot: 51% identical to BTUE_ECOLI: Thioredoxin/glutathione peroxidase BtuE (btuE) from Escherichia coli (strain K12)

KEGG orthology group: K00432, glutathione peroxidase [EC: 1.11.1.9] (inferred from 90% identity to sch:Sphch_1136)

MetaCyc: 51% identical to thioredoxin/glutathione peroxidase BtuE (Escherichia coli K-12 substr. MG1655)
Glutathione peroxidase. [EC: 1.11.1.9]; RXN0-267 [EC: 1.11.1.9, 1.11.1.24]

Predicted SEED Role

"Glutathione peroxidase family protein"

MetaCyc Pathways

• reactive oxygen species degradation (4/4 steps found)
• glutathione-peroxide redox reactions (2/3 steps found)

KEGG Metabolic Maps

• Arachidonic acid metabolism
• Glutathione metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.11.1.24 or 1.11.1.9

Protein Sequence (181 amino acids)

>GFF4082 Glutathione peroxidase (EC 1.11.1.9) @ Thioredoxin peroxidase (EC 1.11.1.15) (Sphingobium sp. HT1-2)
MTAIQQIPLKTIKGADATLADYAGKVVLAVNVASKCGLTPQYEGLEKLYADYRDKGLVVA
GFPANDFGAQEPGSNDEIATFCTTNFGVDFPMFEKIVVSGPEKHPLYAALTSAQPEAQGD
GDSFRERLKGYGMTPNPVPEILWNFEKFVIAKDGSVAARFAPTTAPDDPALVAAIEAELA
K