Protein Info for PS417_20900 in Pseudomonas simiae WCS417
Annotation: guanine deaminase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 61% identical to GUAD_ECOLI: Guanine deaminase (guaD) from Escherichia coli (strain K12)
KEGG orthology group: K01487, guanine deaminase [EC: 3.5.4.3] (inferred from 99% identity to pfs:PFLU4595)MetaCyc: 61% identical to guanine deaminase (Escherichia coli K-12 substr. MG1655)
Guanine deaminase. [EC: 3.5.4.3]
Predicted SEED Role
"Guanine deaminase (EC 3.5.4.3)" in subsystem Purine Utilization or Purine conversions (EC 3.5.4.3)
MetaCyc Pathways
- purine nucleotides degradation II (aerobic) (11/11 steps found)
- purine nucleotides degradation I (plants) (10/12 steps found)
- guanosine nucleotides degradation II (4/4 steps found)
- guanosine nucleotides degradation III (4/4 steps found)
- superpathway of purines degradation in plants (14/18 steps found)
- superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
- drosopterin and aurodrosopterin biosynthesis (5/7 steps found)
- purine nucleobases degradation II (anaerobic) (16/24 steps found)
- purine nucleobases degradation I (anaerobic) (6/15 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 3.5.4.3
Use Curated BLAST to search for 3.5.4.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1N7ULV1 at UniProt or InterPro
Protein Sequence (434 amino acids)
>PS417_20900 guanine deaminase (Pseudomonas simiae WCS417) MPLTRKAYRAALLHSIADPAEVGIEASYEYFEDGLLVIENGQISAVGHASDLLPTLPADI DITHYQDALITPGLIDTHIHLPQTGMVGAYGEQLLDWLNTYTFPCESQFADKAHAEEVAD IFIKELLRNGTTTALVFGSVHPQSVNAFFEAAEKLDLRMIAGKVMMDRNAPDYLTDTAES GYQESKALIERWHGKGRLHYAVTPRFAPTSTPEQLALAGQLLGEYPDLYMQTHISENKQE VEWVKELFPERNGYLDVYDHYKLLGERSVFAHGVHLCDDECARLAETGSAVAFCPTSNFF LGSGLFNLPMAEKHKLNVGLGTDVGGGTSFSLLQTLNEAYKVMQLQGARLSPFKSLYLAT LGGARALRLEDKIGTLQPGTDADFLVLDYNATPLLSYRLKQAKTIAETLFVLMTLGDDRT VLQTYAAGQLVHQR