Protein Info for GFF4077 in Xanthobacter sp. DMC5

Annotation: (2R)-3-sulfolactate dehydrogenase (NADP(+))

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02615: Ldh_2
  • amino acids 7 to 329 (323 residues), 330.9 bits, E=4.4e-103

Best Hits

Swiss-Prot: 57% identical to COMC_CHRSD: (2R)-3-sulfolactate dehydrogenase (NADP(+)) (comC) from Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)

KEGG orthology group: None (inferred from 57% identity to csa:Csal_1771)

MetaCyc: 57% identical to R-sulfolactate oxidoreductase (Chromohalobacter salexigens DSM 3043)
RXN-11690 [EC: 1.1.1.338]

Predicted SEED Role

"Ureidoglycolate dehydrogenase (EC 1.1.1.154)" in subsystem Allantoin Utilization (EC 1.1.1.154)

MetaCyc Pathways

• sulfolactate degradation I (2/3 steps found)
• allantoin degradation IV (anaerobic) (6/9 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.154

Use Curated BLAST to search for 1.1.1.154 or 1.1.1.338

Protein Sequence (334 amino acids)

>GFF4077 (2R)-3-sulfolactate dehydrogenase (NADP(+)) (Xanthobacter sp. DMC5)
MSEQLSLHAARALARSVLIAAGAGRTAADATAEALVAADADGIASHGLSRLPAYADQIRS
GKVKGQAEPALEWTSVSTLRVDAREGLAFPAIAAGLDAAAGRIAESGIVAVSVFASHHAG
VMGHHVEQMAERGLAALAFSNSPQAIAPWGGQAGVFGTNPIAFATPRKDAAPLVIDASLS
KVARGKIMVAAQRGNPIPGDWALDAQGNPTTDPKAALAGTMLPIGDAKGAALVLMVEILA
AALTGGQFGFEAASFFTAEGPSPAIGHLFLVMDPVRLGGPDYLVRLELLLGAILGQDGTR
LPGERRLKARAVSEAEGITIPADLLEDLQRRSAA