Protein Info for GFF4076 in Sphingobium sp. HT1-2

Annotation: Two-component transcriptional response regulator, LuxR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 221 PF00072: Response_reg" amino acids 4 to 112 (109 residues), 93.3 bits, see alignment E=1.1e-30 PF00486: Trans_reg_C" amino acids 145 to 216 (72 residues), 85.6 bits, see alignment E=1.9e-28

Best Hits

Swiss-Prot: 46% identical to QSEB_SALTY: Transcriptional regulatory protein QseB (qseB) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02483, two-component system, OmpR family, response regulator (inferred from 97% identity to sjp:SJA_C1-23110)

Predicted SEED Role

"DNA-binding response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (221 amino acids)

>GFF4076 Two-component transcriptional response regulator, LuxR family (Sphingobium sp. HT1-2)
MRLLIVEDEPSLGQQLRNTLEGAGYAVDLATDGEDGHFLGSTENYDAVVLDLGLPTIDGL
TVLDRWRKEGRSFPVLVLTARDSWSDKVAGLDAGADDYLAKPFQSEELIARLRALIRRAS
GNASSELIAGDVRLDTRSGKVTLKGDPVKLTAQEYKLLSYLLHHKGKVVSRTELIEHIYD
QDFDRDSNTIEVFVTRIRKKLGADVITTIRGLGYSLDEPGR