Protein Info for GFF402 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01210: NAD_Gly3P_dh_N
  • amino acids 8 to 163 (156 residues), 182.1 bits, E=2.3e-57
• PF02558: ApbA
  • amino acids 9 to 115 (107 residues), 40.7 bits, E=5.7e-14
• PF03807: F420_oxidored
  • amino acids 9 to 96 (88 residues), 24 bits, E=1.5e-08
• PF07479: NAD_Gly3P_dh_C
  • amino acids 184 to 323 (140 residues), 191.1 bits, E=3.4e-60
• PF20618: GPD_NAD_C_bact
  • amino acids 244 to 310 (67 residues), 87.9 bits, E=1.6e-28

Best Hits

Swiss-Prot: 100% identical to GPDA_SALA4: Glycerol-3-phosphate dehydrogenase [NAD(P)+] (gpsA) from Salmonella agona (strain SL483)

KEGG orthology group: K00057, glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC: 1.1.1.94] (inferred from 100% identity to sei:SPC_3782)

MetaCyc: 95% identical to glycerol-3-phosphate dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glycerol-3-phosphate dehydrogenase (NAD(P)(+)). [EC: 1.1.1.94]

Predicted SEED Role

"Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94)" in subsystem Glycerol and Glycerol-3-phosphate Uptake and Utilization or Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 1.1.1.94)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (12/12 steps found)
• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (11/13 steps found)
• CDP-diacylglycerol biosynthesis I (4/4 steps found)
• CDP-diacylglycerol biosynthesis II (4/4 steps found)
• glycerol-3-phosphate shuttle (2/2 steps found)
• 1,3-propanediol biosynthesis (engineered) (7/9 steps found)
• CDP-diacylglycerol biosynthesis III (3/5 steps found)
• glucosylglycerol biosynthesis (3/5 steps found)
• phosphatidate biosynthesis (yeast) (3/5 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.94

Protein Sequence (339 amino acids)

>GFF402 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MNQSNASMTVIGAGSYGTALAITLARNGHQVVLWGHDPKHIATLEHDRCNVAFLPDVPFP
DTLHLESDLATALAASRNILVVVPSHVFSDVLRQIKPLMRPDARLVWATKGLEAETGRLL
QDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDETFADDLQQLLHCGKSFRVY
INADFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLTEMSRLGAALGADPATF
MGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVKGAQDKIGQVVEGYRNTKEVRELAHRF
GVEMPITEEIYQVLYCGKNAREAALTLLGRARKEELSRH