Protein Info for GFF3997 in Variovorax sp. SCN45

Annotation: Short-chain dehydrogenase/reductase SDR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 235 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00106: adh_short" amino acids 9 to 197 (189 residues), 158 bits, see alignment E=4.4e-50 PF01370: Epimerase" amino acids 10 to 179 (170 residues), 32.5 bits, see alignment E=1.2e-11 PF08659: KR" amino acids 10 to 175 (166 residues), 34.3 bits, see alignment E=4.8e-12 PF13561: adh_short_C2" amino acids 14 to 234 (221 residues), 142.7 bits, see alignment E=2.9e-45

Best Hits

KEGG orthology group: None (inferred from 91% identity to vpe:Varpa_1673)

Predicted SEED Role

"Short-chain dehydrogenase/reductase SDR"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (235 amino acids)

>GFF3997 Short-chain dehydrogenase/reductase SDR (Variovorax sp. SCN45)
MSDASITSHVLITGAAGALGRAVAQHFLEQGARLALVDHHAGRLAEVFPGLDNSRHLLLA
GDVTSAPGMAGLAEQVLKSFGQIDALVHIAGGFEMGEATHALSRESWDRMMNLNAWSFVA
VTQAVLPSMIERGAGSVVAVTAKVAARGLPAMAAYIASKSALQRLVEAMAAEAAPHGVNV
NSVAPSVLDTPANRQAMPDANPAEWVSTSVAAQTIGFLASPAAAALHGQHLTLDT