Protein Info for GFF3974 in Variovorax sp. SCN45

Annotation: Oxidoreductase, short-chain dehydrogenase/reductase family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 417 signal peptide" amino acids 1 to 42 (42 residues), see Phobius details PF12172: zf-ChsH2" amino acids 36 to 70 (35 residues), 47.5 bits, see alignment 3.1e-16 PF01796: OB_ChsH2_C" amino acids 72 to 136 (65 residues), 48.6 bits, see alignment E=1.6e-16 PF00106: adh_short" amino acids 171 to 362 (192 residues), 80.6 bits, see alignment E=2.9e-26 PF01370: Epimerase" amino acids 174 to 377 (204 residues), 21.7 bits, see alignment E=3e-08 PF13561: adh_short_C2" amino acids 182 to 372 (191 residues), 61.1 bits, see alignment E=3.2e-20

Best Hits

KEGG orthology group: None (inferred from 97% identity to vap:Vapar_1497)

Predicted SEED Role

"Oxidoreductase, short chain dehydrogenase/reductase family" in subsystem Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (417 amino acids)

>GFF3974 Oxidoreductase, short-chain dehydrogenase/reductase family (Variovorax sp. SCN45)
MTMPLIRPPRKNPVLRTRQMNLPPGARGRVALGLTAAAAEGRFELQTCEDCGAVQYPPRE
VCHKCLSAALRWREQGGEGELLGSTTLHHSNDLFFRERLPWRLGLVHLDAGPTLMVHLHG
EVGDAPQRVRVGARLDRAGQAVLIGFPNEGSPHMADDKMLREMTSDPKFRKVLVTDGKTE
TGQAIVRALVKAGADIVWVGHAEPWKKMGDGLDDISALPQVTLVPLDLTNGRQVTELAGS
IGGKVDIVINNAEVHRTFGIGARRGTDVARAEMDINYFGLLRLAQEFGPALKGRSADGVT
GATAWVNLLSIYALSNFPPHGTFSASKAAAHSLAQCLRAEMRPAGIRVINVFPGPIDDEW
NQHTPPPKLAPTALANAIVKALRDGVEDVYPGDVAQEWLERWRDNPKVLERELAAGG