Protein Info for PS417_20280 in Pseudomonas simiae WCS417

Annotation: mechanosensitive ion channel protein MscS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 266 transmembrane" amino acids 22 to 47 (26 residues), see Phobius details amino acids 72 to 92 (21 residues), see Phobius details amino acids 98 to 125 (28 residues), see Phobius details amino acids 146 to 164 (19 residues), see Phobius details amino acids 170 to 186 (17 residues), see Phobius details PF00924: MS_channel_2nd" amino acids 188 to 255 (68 residues), 53.8 bits, see alignment E=8.4e-19

Best Hits

Predicted SEED Role

"Small-conductance mechanosensitive channel"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UD69 at UniProt or InterPro

Protein Sequence (266 amino acids)

>PS417_20280 mechanosensitive ion channel protein MscS (Pseudomonas simiae WCS417)
MDIKQLWLNVQDLWGALDEHPLLHASLGLLVLLVVALLLGRVARYLILHAVKLLGRQPAL
HWLNDLRHNKVFHRLAQMTPSLVIQFGLYLVPDLSKTAILFIGNVALAITILFLVLATSA
LLNALLDIYARTEHARTRSIKGYVQLAKMVLFVFGAIIIVATLIDRSPLLLLSGLGAMSA
VILLVYKDTLLSFVASVQLTSNDMLRVGDWIEMPQVGADGDVVDITLHTVKVQNFDKTIV
SIPTWRLMSESFKNNRQSKWKPYYQT