Protein Info for GFF395 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Pantothenate kinase type III, CoaX-like (EC 2.7.1.33)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 80% identical to COAX_POLSJ: Type III pantothenate kinase (coaX) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K03525, type III pantothenate kinase [EC: 2.7.1.33] (inferred from 80% identity to pol:Bpro_4044)

Predicted SEED Role

"Pantothenate kinase type III, CoaX-like (EC 2.7.1.33)" in subsystem Coenzyme A Biosynthesis (EC 2.7.1.33)

MetaCyc Pathways

superpathway of coenzyme A biosynthesis I (bacteria) (9/9 steps found)
superpathway of coenzyme A biosynthesis II (plants) (9/10 steps found)
superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
phosphopantothenate biosynthesis I (4/4 steps found)
phosphopantothenate biosynthesis II (1/3 steps found)

KEGG Metabolic Maps

Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.33

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (256 amino acids)

>GFF395 Pantothenate kinase type III, CoaX-like (EC 2.7.1.33) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTFLALDVGNTRLKWALYDAPCVGATLLASGAQFLENIETLEDGDWRQLPAPQWVLGCVV
AGDAVKRRVGEQLELWDVTPHWVVSSSAEAGVFNGYDHPARLGSDRWVAMIGARQRLLAR
GRARPCVVVMVGTAVTVEAIDTEGRFLGGIILPGHGIMLRALESGTAGLHVPTGEVRDFP
TNTSDALTSGGTFAIAGAVQRMVENLRRHCGEEPACFMTGGAGWKMAPSMSTEVELVESL
IFDGLLEIANRRLALV