Protein Info for GFF3927 in Variovorax sp. SCN45
Annotation: N-acetylornithine aminotransferase (EC 2.6.1.11)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 55% identical to ARGD1_BORBR: Acetylornithine aminotransferase 1 (argD1) from Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
KEGG orthology group: K00818, acetylornithine aminotransferase [EC: 2.6.1.11] (inferred from 97% identity to vpe:Varpa_1607)MetaCyc: 47% identical to bifunctional acetylornithine transaminase/4-aminobutyrate--2-oxoglutarate transaminase (Synechocystis sp. PCC 6803)
4-aminobutyrate transaminase. [EC: 2.6.1.19]; Acetylornithine transaminase. [EC: 2.6.1.19, 2.6.1.11]
Predicted SEED Role
"Acetylornithine aminotransferase (EC 2.6.1.11)" in subsystem Arginine Biosynthesis extended (EC 2.6.1.11)
MetaCyc Pathways
- L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
- superpathway of arginine and polyamine biosynthesis (15/17 steps found)
- L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
- L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
- L-ornithine biosynthesis I (5/5 steps found)
- superpathway of 4-aminobutanoate degradation (3/3 steps found)
- 4-aminobutanoate degradation I (2/2 steps found)
- 4-aminobutanoate degradation II (2/2 steps found)
- 4-aminobutanoate degradation III (2/2 steps found)
- GABA shunt I (3/4 steps found)
- GABA shunt II (3/4 steps found)
- 4-aminobutanoate degradation V (5/7 steps found)
- superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
- nicotine degradation I (pyridine pathway) (5/17 steps found)
KEGG Metabolic Maps
- Alanine and aspartate metabolism
- Arginine and proline metabolism
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Butanoate metabolism
- Glutamate metabolism
- Lysine biosynthesis
- Propanoate metabolism
- Urea cycle and metabolism of amino groups
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.19
Use Curated BLAST to search for 2.6.1.11 or 2.6.1.19
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (402 amino acids)
>GFF3927 N-acetylornithine aminotransferase (EC 2.6.1.11) (Variovorax sp. SCN45) MSATAQPTSPHVMNTYGRLPIALSHGQGCRVWDTTGKAYIDGLGGIAVNTLGHNHPELVP ALQDQLTKLIHSSNYYHVTGQEQLATKLTEISGLTNAFFCCTGLEANEAALKLARKFGHD KGIERPEIVVYEAAFHGRSIATLSATGNPKVQAGFGPLVEGFIRVPLNDIEALKKATEGN PNVVAVFFETIQGEGGIHPMRVEYLKQVRALCDERDWLMMIDEVQCGMGRTGKWFAHQWA GIKPDVMPLAKGLGSGVPIGAVVAGPKAANIFGPGNHGTTFGGNPLAMRAGVETIRIMEE HKLLENAATVGAHLKAALEREIGGLPGVKEIRGQGLMIGIELDRPCGVILNRACDAGLLL SVTADKVIRLVPPLILTIAEADEIVAILAPIVKAFLSEPAPQ