Protein Info for GFF3908 in Sphingobium sp. HT1-2

Annotation: DNA polymerase III alpha subunit (EC 2.7.7.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1180 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details TIGR00594: DNA polymerase III, alpha subunit" amino acids 6 to 1035 (1030 residues), 1099.9 bits, see alignment E=0 PF02811: PHP" amino acids 10 to 176 (167 residues), 99.8 bits, see alignment E=4.4e-32 PF07733: DNA_pol3_alpha" amino acids 295 to 560 (266 residues), 336 bits, see alignment E=3.5e-104 PF17657: DNA_pol3_finger" amino acids 563 to 723 (161 residues), 206.1 bits, see alignment E=4.6e-65 PF14579: HHH_6" amino acids 798 to 896 (99 residues), 92.2 bits, see alignment E=3.8e-30

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 86% identity to sch:Sphch_0794)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1180 amino acids)

>GFF3908 DNA polymerase III alpha subunit (EC 2.7.7.7) (Sphingobium sp. HT1-2)
MSHSAFVPLRIFSSFTMLEGAIDPKKIAKQAKALGFPAAAITDRNGLYGSMAFSDGCKGE
GVQPIVGAMLGVVRPGRPSNAPAVHDWIALYAQDAGGYDNICALVSMAHLDRPLEEVPHV
TLDMLEGRTDGVIALTAGGEGAIARLFAEDQPDAALAYADRLQALFPDRLYVEICRRLDP
VEGKAEPQLLDLAYDRNLPLVATNPTCFAEPEFHAAHDVMLCIADGAYVETPDRRTSSPD
AWMKPAAEMKRLFEDLPEALANTLVVAQRCAVMAPKRKPILPSLAGDIEGEGIMLRDQSI
AGLEARLEKAGIIADEARQPYFERLKFEMDIIIQMGFPGYFLIVADFIKWAKDHDIPVGP
GRGSGAGSLVAWALTITDLDPLQLGLLFERFLNPERVSMPDFDIDFCETRRGEVIRYVQQ
KYGSDHVAQIITFGKLKARAVLKDTGRVMQMSYGQVDRLAKLVPNHPTDPWTLERSLNGV
AEFKAEYDNDNQVKRLIDYAMKLEGFPRHSSTHAAGVVIGDRPLSQLVPLYRDPRSDMPV
TQFDMKFVEGAGLVKFDFLGLKTLSVLQKAVQLLKGRGVTVDLDTLAWDDAKVYELLQRG
DTVGVFQLESEGMRKTLAAVRPTNFGDIIALVSLYRPGPMDNIPMFGRRKNGQEEIEYPH
ILLKPILEETYGIFVYQEQVMQAAQILAGYSLGDADLLRRAMGKKIKAEMDAQRLRFVEG
CAKSDIKPAKANELFDLIDKFAGYGFNKSHAAAYALLAYQTAWLKAHYPAEFYAGSMAFD
IHLTEKLTVFVDDMRRMGMTCLPPDLNQSEADFTVEAVPFEGDDPRLGFAVRYALGGLKG
VGEKAMEQLVAEREANGPFKHLDDLADRIEPRLLNRRQLESLAAAGAFDTIHADRAGVHA
AAETLLSVAASAAQARESGQGGLFGDVETAHEDVRIPPHQAWTVSDRMAQEKEAFGFYFS
AHPVDRFRHLADARGAKSYGEICSQPMGMPNAEGRVMGIMAAMVEDVRWRETRRGARYAN
ATFSDQSGQFQASCFDEDACKQIEELAREGDCALLHVELDRLPGEETPRVTVRRMEPFRE
IANVSRMELVLDIEMVEAVAKLAAILSGSRGGRCEVFVRAPIGDGKAARVFLGDDFTLGA
DQVDAISGIAGLTVHNLARMEAKSDGYRTRHRRSAMRLVG