Protein Info for GFF3905 in Sphingobium sp. HT1-2

Annotation: Lipoprotein-releasing system ATP-binding protein LolD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 228 PF00005: ABC_tran" amino acids 24 to 172 (149 residues), 110.6 bits, see alignment E=9.4e-36

Best Hits

Swiss-Prot: 77% identical to LOLD_NOVAD: Lipoprotein-releasing system ATP-binding protein LolD (lolD) from Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)

KEGG orthology group: K09810, lipoprotein-releasing system ATP-binding protein [EC: 3.6.3.-] (inferred from 91% identity to sjp:SJA_C1-17410)

MetaCyc: 49% identical to lipoprotein release complex - ATP binding subunit (Escherichia coli K-12 substr. MG1655)
RXN-22427

Predicted SEED Role

"Lipoprotein releasing system ATP-binding protein LolD"

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-

Use Curated BLAST to search for 3.6.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (228 amino acids)

>GFF3905 Lipoprotein-releasing system ATP-binding protein LolD (Sphingobium sp. HT1-2)
MNDVLKVSGLSRSFTQGGVTIDVLRGVDLTVGPGEIVALLGPSGSGKSTLLQAVGLLEGG
FDGSIRIAGEEAAKLDNDGRTRLRRDALGFVYQFHHLLPDFNATENVVLPQVIKDATMDA
ARTRAESLLTALGLGHRLDHRPSQLSGGEQQRVAVARALANRPALVLADEPTGNLDERTA
DVVLAEFLRLVRGEGSAALVATHNERLAEKMDRVVRLHEGRLEEASAR