Protein Info for GFF3900 in Xanthobacter sp. DMC5

Annotation: Phosphomannomutase/phosphoglucomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02878: PGM_PMM_I
  • amino acids 26 to 154 (129 residues), 92.8 bits, E=3.1e-30
• PF02879: PGM_PMM_II
  • amino acids 176 to 272 (97 residues), 86.4 bits, E=3.6e-28
• PF02880: PGM_PMM_III
  • amino acids 278 to 390 (113 residues), 65.8 bits, E=7.6e-22
• PF00408: PGM_PMM_IV
  • amino acids 419 to 483 (65 residues), 27 bits, E=7.6e-10

Best Hits

KEGG orthology group: None (inferred from 95% identity to xau:Xaut_1929)

Predicted SEED Role

"Phosphoglucosamine mutase (EC 5.4.2.10) / Phosphomannomutase (EC 5.4.2.8)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis or Alginate metabolism or Mannose Metabolism (EC 5.4.2.10, EC 5.4.2.8)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• colanic acid building blocks biosynthesis (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• dTDP-β-L-rhamnose biosynthesis (5/5 steps found)
• GDP-mannose biosynthesis (4/4 steps found)
• UDP-α-D-glucose biosynthesis (2/2 steps found)
• sucrose biosynthesis I (from photosynthesis) (7/9 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• sucrose degradation IV (sucrose phosphorylase) (3/4 steps found)
• β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• glucose and glucose-1-phosphate degradation (3/5 steps found)
• sucrose biosynthesis II (5/8 steps found)
• glycogen biosynthesis I (from ADP-D-Glucose) (2/4 steps found)
• starch degradation V (2/4 steps found)
• chitin biosynthesis (5/9 steps found)
• D-galactose degradation I (Leloir pathway) (2/5 steps found)
• glucosylglycerol biosynthesis (2/5 steps found)
• glycogen biosynthesis III (from α-maltose 1-phosphate) (4/8 steps found)
• glycogen degradation I (4/8 steps found)
• starch degradation III (1/4 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (8/14 steps found)
• glycogen degradation II (2/6 steps found)
• CDP-6-deoxy-D-gulose biosynthesis (1/5 steps found)
• β-(1,4)-mannan degradation (2/7 steps found)
• peptidoglycan recycling I (7/14 steps found)
• starch biosynthesis (4/10 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of dTDP-glucose-derived O-antigen building blocks biosynthesis (6/19 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• streptomycin biosynthesis (2/18 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Fructose and mannose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.4.2.10

Use Curated BLAST to search for 5.4.2.10 or 5.4.2.8

Protein Sequence (499 amino acids)

>GFF3900 Phosphomannomutase/phosphoglucomutase (Xanthobacter sp. DMC5)
MFPTPKPVLTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMG
VKPEIVTGHDFRSYSSSIKLALVSGLMAAGIKVHDIGLAMSPMAYFAQFALDVPAVAMVT
ASHNDNGWTGVKMGVNRPLTFGPDEMTRLKEIVLGAKFDLKGGGAYVFVENFPEVYIKDL
TNRPKLKHPIKAVVACGNGTAGAFAPKILEALGVEVVPLDTELDHTFPKYNPNPEDMEML
HAMRDAVLEHKADVALGFDGDGDRCGVVDNTGEEIFADKVGVLLARDLAKIYPNSTFVVD
VKSTGLFATDPELIKLGVKADYWKTGHSYMKRRVNETGALVGFEKSGHYFFNKPVGRGYD
DGLVSAIAVLDMLDRNPGKKLSELREALPKTWSSPTMSPHCADEAKYGVVAKVVEHYEKL
AAEGATVTGQKIRDLVTVNGVRVTCEDGSWGLLRASSNKPELVVVVESPVSEARMREMFK
EIDGVLRQHPGIGEYNQTI