Protein Info for GFF389 in Sphingobium sp. HT1-2

Annotation: Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00521: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase
  • amino acids 3 to 405 (403 residues), 424.7 bits, E=1.8e-131
• PF02441: Flavoprotein
  • amino acids 4 to 173 (170 residues), 120.8 bits, E=4.5e-39
• PF04127: DFP
  • amino acids 199 to 380 (182 residues), 239.1 bits, E=3.3e-75

Best Hits

KEGG orthology group: K13038, phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase [EC: 4.1.1.36 6.3.2.5] (inferred from 85% identity to sch:Sphch_1596)

Predicted SEED Role

"Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)" in subsystem Coenzyme A Biosynthesis (EC 4.1.1.36, EC 6.3.2.5)

MetaCyc Pathways

• superpathway of coenzyme A biosynthesis I (bacteria) (8/9 steps found)
• superpathway of coenzyme A biosynthesis III (mammals) (5/5 steps found)
• coenzyme A biosynthesis I (bacteria) (4/4 steps found)
• coenzyme A biosynthesis II (eukaryotic) (4/4 steps found)
• coenzyme A biosynthesis III (archaea) (3/4 steps found)
• taurine biosynthesis II (1/4 steps found)

KEGG Metabolic Maps

• Pantothenate and CoA biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.36 or 6.3.2.5

Protein Sequence (414 amino acids)

>GFF389 Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5) (Sphingobium sp. HT1-2)
MTQRVLLIVSGGIAAYKSLELVRQLRKRGIAVRAVLTQSAQQFVTPLSLGVLTEDHVYGD
MFDLKEEREIGHIQLSRQADLIVVAPATANILAKMAAGIADDLATTILLATDKPVLAVPA
MNVRMWHHKATQRNLAQLHADGVHIMTPDDGEMACGEYGKGRLPEPEAIAAEIGRLLTDP
ALPDPLAGQPDFAGADEPLTGRHILVTAGPTHEPIDPVRYIANRSSGKQGFAIAAAAARA
GAKVTLVAGPVHLPTPAGVDRIDVETAREMLAAVEGALPADAAIMVAAVADWRTADAAEQ
KLKKDGSGQPAPLALVENPDILATLGHHVRRPRLLIGFAAETQKIAEHAQAKLTRKGADW
IVANDVSGDVMGGDSNSVQIVTSTGIESWAAMAKSDVATKLIEKVANALSPAAD