Protein Info for GFF3887 in Xanthobacter sp. DMC5

Annotation: Phosphogluconate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 611 TIGR01196: phosphogluconate dehydratase" amino acids 9 to 608 (600 residues), 1014.7 bits, see alignment E=0 PF00920: ILVD_EDD_N" amino acids 72 to 385 (314 residues), 339.7 bits, see alignment E=1.7e-105 PF24877: ILV_EDD_C" amino acids 412 to 605 (194 residues), 186.1 bits, see alignment E=4.7e-59

Best Hits

Swiss-Prot: 67% identical to EDD_RHIME: Phosphogluconate dehydratase (edd) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01690, phosphogluconate dehydratase [EC: 4.2.1.12] (inferred from 87% identity to xau:Xaut_1698)

MetaCyc: 64% identical to phosphogluconate dehydratase (Escherichia coli K-12 substr. MG1655)
Phosphogluconate dehydratase. [EC: 4.2.1.12]

Predicted SEED Role

"Phosphogluconate dehydratase (EC 4.2.1.12)" in subsystem Entner-Doudoroff Pathway (EC 4.2.1.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (611 amino acids)

>GFF3887 Phosphogluconate dehydratase (Xanthobacter sp. DMC5)
MAAQHTLDARVGEITERIAQRSQDGRRRYLDRIEAAAQRRPQRQALGCANQAHGFAACGP
SDKAMLRAGEGPSLGIVTAYNDMLSAHRPYERYPELLREAAREAGGAALVAGGVPAMCDG
ITQGEAGMELSLFSRDVIALSTAVALSHQTFDAAVFLGICDKIVPGLVIGALSFGHLPAV
FIPSGPMTSGLPNNEKSRIRQLYAEGKVGRDALLEAESQSYHGPGTCTFYGTANTNQMLM
EIMGLHLPGASFVTPDTPLRDALTKAAAQRALAITALGNEHIPAGRMLDEKAFVNGIVGL
HATGGSTNHTLHLVAMAAAAGIALSWDDFSALAEVTPLLARVYPNGSADVNHFHAAGGVP
FVVRELLSAGLLHADAETILGRGLEAYTREPVLADDGSLDWRDGAATSGDDKVLRGVAAP
FQSTGGLRVLDGSLGRAVIKTSAVAPERHVIEAPAKVFHSQEELQAAFKAGTLTGDLVAV
VRFQGPKANGMPELHKLMPPLGVLQDRGQRVALVTDGRLSGASGKVPAAIHVTPEALDGG
AIARIRDGDMIRVDAVAGRLEVLVPPGEWAARPSATADLSANHTGVGRELFAPFRAAVGE
AENGASIFAGA