Protein Info for GFF3878 in Xanthobacter sp. DMC5

Annotation: Chromosomal replication initiator protein DnaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 TIGR00362: chromosomal replication initiator protein DnaA" amino acids 14 to 481 (468 residues), 469.8 bits, see alignment E=4.9e-145 PF11638: DnaA_N" amino acids 14 to 74 (61 residues), 76 bits, see alignment E=2.3e-25 PF00308: Bac_DnaA" amino acids 144 to 305 (162 residues), 177.9 bits, see alignment E=2.8e-56 PF08299: Bac_DnaA_C" amino acids 394 to 462 (69 residues), 106.8 bits, see alignment E=7e-35

Best Hits

Swiss-Prot: 62% identical to DNAA_BRASB: Chromosomal replication initiator protein DnaA (dnaA) from Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)

KEGG orthology group: K02313, chromosomal replication initiator protein (inferred from 62% identity to bbt:BBta_0001)

Predicted SEED Role

"Chromosomal replication initiator protein DnaA" in subsystem DNA-replication

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (486 amino acids)

>GFF3878 Chromosomal replication initiator protein DnaA (Xanthobacter sp. DMC5)
MDCASNPSASAGPWDRVLQRLREEIGEEKFTSWFARMDLDALTADVVRLSVPTRFLKSWI
QENYLPRITDIWAEETGARRRVDLAVRNAFARPVALKASAPREVVSERTERPVESKPAPR
ASEARGEVREMVPTGGDVASGSPLDPRLTFESFVVGKSNSLAFAAARKVAETPAGAAPVY
NPLYLHAAVGLGKTHLLQAVARAGAAHGRRTTYLTAERFMYGFVSALKSHSAIAFKDTLR
TIDTLVIDDLQFLKGNNLQQEFCHTLNALLDGGRQVVLAADCLPGELEHLDERVRSRLAG
GLVVELAPLEEDLRLEILKARYQTLAEQHQGFAVPAPVLEFLARSVGQSGRDLDGALNKL
LAFNQLTGEPVTLDMAENAVKDLIRPTDPKRVRVDDILRVVAKHYNVSRADLLSQRRTAT
VVKPRQIAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRKIDGLVATDRALADEIEVLK
RLALES