Protein Info for GFF3851 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Sensory histidine kinase BaeS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 467 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 166 to 187 (22 residues), see Phobius details PF00672: HAMP" amino acids 184 to 235 (52 residues), 57.9 bits, see alignment 1.5e-19 PF00512: HisKA" amino acids 240 to 304 (65 residues), 51.9 bits, see alignment E=9.9e-18 PF02518: HATPase_c" amino acids 349 to 460 (112 residues), 85.3 bits, see alignment E=6.1e-28

Best Hits

Swiss-Prot: 89% identical to BAES_ECOLI: Signal transduction histidine-protein kinase BaeS (baeS) from Escherichia coli (strain K12)

KEGG orthology group: K07642, two-component system, OmpR family, sensor histidine kinase BaeS [EC: 2.7.13.3] (inferred from 99% identity to see:SNSL254_A2316)

MetaCyc: 89% identical to sensor histidine kinase BaeS (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

"Sensory histidine kinase BaeS"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (467 amino acids)

>GFF3851 Sensory histidine kinase BaeS (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKVWRPGITGKLFLAIFATCIVLLISMHWAVRVSFERGFIDYIKHGNEQRLQMLGDALGD
QYQQHGNWRFLRNNDRFVFQILRSFEHDNDRDKPGPGMPPHGWRTQFWVVDQNGRVLVGP
RGPVPHDGTRRPILVNDVEVGAIIASPVERLTRNTDINFDMQQRRASWMIVALSTLLAAL
ATFLLARGLLAPVKRLVEGTHRLAAGDFTTRVTPTSADELGKLAQDFNQLASTLEKNQQM
RRDFMADISHELRTPLAVLRGELEAIQDGVRQFTPESVTSLQAEVGTLTKLVDDLHQLSL
SDEGALAYQKTTVDLVPLLEVAGGAFRERFTSRGLTLHYALPDSMTVFGDPDRLMQLFNN
LLENSLRYTDSGGGLHISAEQRDKSLFLTFADSAPGVSDEQLQKLFDRFYRTEVSRNRAS
GGSGLGLAICVNIVHAHNGHLHAAHSPFGGVSITVELPLDRDLQREV