Protein Info for GFF3840 in Variovorax sp. SCN45

Annotation: Uroporphyrinogen-III synthase (EC 4.2.1.75)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02602: HEM4
  • amino acids 17 to 248 (232 residues), 77.5 bits, E=4.5e-26

Best Hits

KEGG orthology group: K01719, uroporphyrinogen-III synthase [EC: 4.2.1.75] (inferred from 84% identity to vpe:Varpa_1514)

Predicted SEED Role

"Uroporphyrinogen-III synthase (EC 4.2.1.75)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.2.1.75)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glutamate (9/10 steps found)
• tetrapyrrole biosynthesis I (from glutamate) (6/6 steps found)
• superpathway of heme b biosynthesis from glycine (6/8 steps found)
• tetrapyrrole biosynthesis II (from glycine) (3/4 steps found)
• adenosylcobalamin biosynthesis II (aerobic) (23/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (22/36 steps found)
• superpathway of bacteriochlorophyll a biosynthesis (6/26 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.75

Protein Sequence (256 amino acids)

>GFF3840 Uroporphyrinogen-III synthase (EC 4.2.1.75) (Variovorax sp. SCN45)
MTARPVIVTRPEREAAQWVSELRAAGLDAVALPLIVIAPVADAQPLRAAWQRLGSYAALM
FVSATAVEHFFQHEAPGMTAGRRFWATGPGTTRALLRSGVPPEQIDAPPPEATRFDSEAL
WERVQGQVTAGVRVLIVRGGDDSGQPAGRDWLAREIDAAGGLRDTVVAYRRLPPSLDVVQ
LRIATDGAQGRAIWLFSSSEAIGNLQRAMPGTDWHAASAVATHARIGEAARAAGFGALRV
CTPLQDALIASIESLA