Protein Info for PS417_19490 in Pseudomonas simiae WCS417

Annotation: mechanosensitive ion channel protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 721 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 136 to 160 (25 residues), see Phobius details amino acids 191 to 208 (18 residues), see Phobius details amino acids 219 to 241 (23 residues), see Phobius details amino acids 261 to 279 (19 residues), see Phobius details amino acids 290 to 310 (21 residues), see Phobius details amino acids 335 to 359 (25 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 410 to 433 (24 residues), see Phobius details amino acids 453 to 475 (23 residues), see Phobius details amino acids 496 to 518 (23 residues), see Phobius details amino acids 525 to 553 (29 residues), see Phobius details PF21088: MS_channel_1st" amino acids 499 to 540 (42 residues), 36.6 bits, see alignment 5.2e-13 PF00924: MS_channel_2nd" amino acids 542 to 606 (65 residues), 60 bits, see alignment E=2.9e-20 PF21082: MS_channel_3rd" amino acids 613 to 698 (86 residues), 26.7 bits, see alignment E=9.3e-10

Best Hits

KEGG orthology group: None (inferred from 97% identity to pfs:PFLU4375)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7TZN2 at UniProt or InterPro

Protein Sequence (721 amino acids)

>PS417_19490 mechanosensitive ion channel protein (Pseudomonas simiae WCS417)
MLSRLFALPCYCLIALLTLLPLTPAHAVGLPGLLGNTNKTQPQAQVPLGQSLDEVIKTLE
NDQQRTQLLSDLKKLREATKKAQPAAEEGVLGLIGGTLANLESQFSGADSPLGRWSNEVD
LAKEELSALMLPANEWLPIIFGFALILAVWSLLAAALIWLSHRVRERFGLPEELPQHPRT
WDMVRFALRKLGPWLIALVITVYLSYALPSSLGKSLAMVLAYALVVGTCFSAICVIAFSV
LDGPHRHRALYILRHQAFRPLWWIGSFAAFGEALSDPRLVTALGQHLSHTAATVANVMAA
LSTGVFILRFRRPIAHLIRNQPLSRRLTRRALSDTIEIIGSFWYIPALLLVGISLFATFV
SAGDTSTALRQSLLCTVLLVLCMVINGLVRRHALKPQRGHKRHALYSERLKSFVYTLAHL
VVWLAFIELGLRVWGLSLIRFTEGDGHEVSVKLFGLAGTLLFAWLIWILSDTAIHHALTR
SRKGLANARAQTMMPLIRNVLFVTIFIIAAIVALANMGMNVTPLLAGAGVIGLAIGFGAQ
SLVADLITGLFIIIEDSLAIDDYVDVGGHLGTVEGLTIRTVRLRDIDGIVHTIPFSEIKS
IKNYSREFGYAIFRVAIPYNMEIDDAIKLMRDVGQKMRNDPLQRRNIWSPLEIQGVESFE
SGSAILRARFKTAPIKQWEVSRAFNLSLKRHLDEAGLDLATPRLSVQVVTAGTVQEKDQQ
Q