Protein Info for GFF3802 in Xanthobacter sp. DMC5

Annotation: Phenylacetate-coenzyme A ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 143 to 279 (137 residues), 33.5 bits, E=1.1e-12

Best Hits

KEGG orthology group: K01912, phenylacetate-CoA ligase [EC: 6.2.1.30] (inferred from 90% identity to xau:Xaut_1866)

Predicted SEED Role

"Phenylacetate-coenzyme A ligase (EC 6.2.1.30)" in subsystem Aromatic amino acid interconversions with aryl acids (EC 6.2.1.30)

MetaCyc Pathways

• phenylacetate degradation I (aerobic) (9/9 steps found)
• superpathway of phenylethylamine degradation (10/11 steps found)
• penicillin G and penicillin V biosynthesis (1/4 steps found)
• phenylacetate degradation II (anaerobic) (1/4 steps found)
• L-phenylalanine degradation IV (mammalian, via side chain) (4/9 steps found)
• anaerobic aromatic compound degradation (Thauera aromatica) (3/27 steps found)

KEGG Metabolic Maps

• Phenylalanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.30

Use Curated BLAST to search for 6.2.1.30

Protein Sequence (414 amino acids)

>GFF3802 Phenylacetate-coenzyme A ligase (Xanthobacter sp. DMC5)
MTDPNRHYDASETRDPEAREQALMQALSAQVAHAKAKAPYFAALFKDVDPAAITSRAALA
QLPVTRKSDLLEIQPRSYPFGGLNATPPGRLARIFMSPGPIYDVEGHGPDFWRFARGLFA
AGFRAGDIVHNSFSYHLTPAGSMIESGAHALGCAVVPAGVGQTDLQLRAIADIRPQGYGG
TPSFLKILVDKARETGTDISSLTKALVSGEAFLPAHRAELKAAGITARQCYGTADLGLVA
YESEAEDGMIVDEGCLVEILRPGTGDPVEAEGEVGEVVVTLFEPDYPLVRFATGDLSAVM
PGTSTCGRTNIRLRGWMGRADQTTKIRGMFVHPVQVQAAVKKHPAVAKARLVVDRAGDQD
DMALEIEVADAAALSQDALLEDIRSATKLRGRLVVLSPGTLPADAKTIEDRRPV