Protein Info for GFF3798 in Sphingobium sp. HT1-2

Annotation: Transcriptional regulator, AcrR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 217 PF00440: TetR_N" amino acids 24 to 70 (47 residues), 55.2 bits, see alignment 5e-19 PF14246: TetR_C_7" amino acids 95 to 212 (118 residues), 94.2 bits, see alignment E=5.8e-31

Best Hits

KEGG orthology group: None (inferred from 65% identity to sch:Sphch_1727)

Predicted SEED Role

"Transcription regulator of multidrug efflux pump operon, TetR (AcrR) family" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (217 amino acids)

>GFF3798 Transcriptional regulator, AcrR family (Sphingobium sp. HT1-2)
MTCPEKALAPSRREARRLDRRQTILEVAARHFLENGYAATSMSAIAAILGGSKGTLWNHF
PSKEELFRAVLENATSTYRARLSEILDPGGDLPSTLHRTALSLLEKVTSPEAIALHRLIA
SEGGRFPEMSRIFYEMAPSHTRMLLARFLEGAMDRGQLRRDDPDKAARVLMRLTTSGCHE
LLLLSQIERVTPQQMESDAAFAVDIFLRAYGADAMTR