Protein Info for GFF3778 in Xanthobacter sp. DMC5

Annotation: putative signaling protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 15 to 176 (162 residues), 105.6 bits, see alignment E=1.1e-34 PF00990: GGDEF" amino acids 18 to 173 (156 residues), 114.5 bits, see alignment E=4.2e-37 PF00563: EAL" amino acids 197 to 426 (230 residues), 240.6 bits, see alignment E=1.5e-75

Best Hits

KEGG orthology group: None (inferred from 81% identity to xau:Xaut_1741)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (443 amino acids)

>GFF3778 putative signaling protein (Xanthobacter sp. DMC5)
VSDANEVARGPWQSEYLALHDPVTSLPNRLLMMEFLAGALSSPQEGRRTLAVFALDIDNF
RQLNEMYGLASGDLILAETARRLRRCVRDNDLVARVGADEFILVATGLADSKAVDGLHRR
LQAALSVPVALPSGAVAYPQADMGIALAPLDAHEPDSLIHCAELALNRAKEEGPGACCYF
AADMNDEMAGRRTLEGDLRRAIVSDEFVLLFQPRCDARTLELLGVEALIRWDHPQLGRLA
PDEFVPIAEKSGLVIPLGEWVLRKACDTISRLPELNVSVNVSVVQFRNGELVGTVESALR
ATSLPAHRLELEITESVLIENTDKALDILEGLKKLGVRLSMDDFGTGYSSLGYLRTFPFD
ALKIDRRFVGDLDQSKGALAIVQAILGLGRALGMQVVAEGVETESQLAVLKADSCDEVQG
FYLGRPMTEEALRAYIAERRLAS