Protein Info for PS417_19335 in Pseudomonas simiae WCS417

Annotation: isochorismatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00857: Isochorismatase
  • amino acids 24 to 192 (169 residues), 112.3 bits, E=1.4e-36

Best Hits

Swiss-Prot: 39% identical to YDDQ_BACSU: Uncharacterized isochorismatase family protein YddQ (yddQ) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 99% identity to pfs:PFLU4342)

Predicted SEED Role

"Isochorismatase (EC 3.3.2.1)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. (EC 3.3.2.1)

MetaCyc Pathways

• superpathway of chorismate metabolism (44/59 steps found)
• 2,3-dihydroxybenzoate biosynthesis (2/3 steps found)
• enterobactin biosynthesis (5/11 steps found)
• vibriobactin biosynthesis (2/9 steps found)
• bacillibactin biosynthesis (4/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Biosynthesis of siderophore group nonribosomal peptides

Isozymes

Compare fitness of predicted isozymes for: 3.3.2.1

Use Curated BLAST to search for 3.3.2.1

Sequence Analysis Tools

See A0A1N7TZK0 at UniProt or InterPro

Protein Sequence (196 amino acids)

>PS417_19335 isochorismatase (Pseudomonas simiae WCS417)
MSVPKTMFQLSGRGYAAANLSHATLVIIDAQKEYLSGPLALSGMDAAVGNIKQLVSAARN
AGRPIVHVRHLGTVGGLFDPQGERGEFIPGLEPEGDETIIGKLLPSAFHGTGLEKHLQDL
GSLDLIVCGFMSHSSVSTTVRAAKNLGFRCTLVEDACATRDLPYKGGILSAEHVQQTEMA
IMADNFATLALTKDLI