Protein Info for GFF3761 in Sphingobium sp. HT1-2

Annotation: Adenine phosphoribosyltransferase (EC 2.4.2.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01090: adenine phosphoribosyltransferase
  • amino acids 7 to 172 (166 residues), 188.3 bits, E=5.8e-60
• PF00156: Pribosyltran
  • amino acids 48 to 145 (98 residues), 51.1 bits, E=5e-18

Best Hits

Swiss-Prot: 62% identical to APT_SPHAL: Adenine phosphoribosyltransferase (apt) from Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)

KEGG orthology group: K00759, adenine phosphoribosyltransferase [EC: 2.4.2.7] (inferred from 84% identity to sch:Sphch_2678)

MetaCyc: 52% identical to adenine phosphoribosyltransferase (Sinorhizobium meliloti 1021)
Adenine phosphoribosyltransferase. [EC: 2.4.2.7]

Predicted SEED Role

"Adenine phosphoribosyltransferase (EC 2.4.2.7)" in subsystem Purine conversions or cAMP signaling in bacteria (EC 2.4.2.7)

MetaCyc Pathways

• superpathway of purine nucleotide salvage (11/14 steps found)
• adenine and adenosine salvage II (2/2 steps found)
• guanine and guanosine salvage II (2/2 steps found)
• adenine and adenosine salvage I (1/2 steps found)
• guanine and guanosine salvage I (1/2 steps found)
• adenine salvage (1/3 steps found)
• superpathway of guanine and guanosine salvage (1/3 steps found)
• glyphosate degradation III (2/7 steps found)
• (aminomethyl)phosphonate degradation (2/8 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.7

Protein Sequence (178 amino acids)

>GFF3761 Adenine phosphoribosyltransferase (EC 2.4.2.7) (Sphingobium sp. HT1-2)
MSIDSLTALVRTIPDFPKPGIQFRDITTLLADGPGLAELIDQMAKVAGPLDPDLIVGVEA
RGFILGAALALALGKGFVPVRKKGKLPGKTVGIDYVLEYGTDRLELHEGQVPQDARVLLV
DDLIATGGTAQAAARLLREQGAQVLMALFAIDLPDLGGLAALEQDGVPSRAILLFEGD