Protein Info for GFF3745 in Sphingobium sp. HT1-2

Annotation: N-acetylornithine aminotransferase (EC 2.6.1.11)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00707: transaminase, acetylornithine/succinylornithine family
  • amino acids 7 to 386 (380 residues), 460.9 bits, E=1.5e-142
• PF00202: Aminotran_3
  • amino acids 17 to 386 (370 residues), 402.3 bits, E=1e-124

Best Hits

Swiss-Prot: 56% identical to ARGD1_CAUVC: Acetylornithine aminotransferase 1 (argD1) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K00821, acetylornithine/N-succinyldiaminopimelate aminotransferase [EC: 2.6.1.11 2.6.1.17] (inferred from 89% identity to sch:Sphch_2662)

MetaCyc: 48% identical to succinylornithine transaminase subunit (Pseudomonas aeruginosa)
Succinylornithine transaminase. [EC: 2.6.1.81]; Ornithine aminotransferase. [EC: 2.6.1.81, 2.6.1.13]; Acetylornithine transaminase. [EC: 2.6.1.81, 2.6.1.13, 2.6.1.11]

Predicted SEED Role

"Acetylornithine aminotransferase (EC 2.6.1.11)" in subsystem Arginine Biosynthesis extended (EC 2.6.1.11)

MetaCyc Pathways

• aspartate superpathway (25/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
• L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• L-arginine biosynthesis I (via L-ornithine) (8/9 steps found)
• L-ornithine biosynthesis II (3/3 steps found)
• L-proline biosynthesis III (from L-ornithine) (3/3 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (7/9 steps found)
• L-arginine degradation II (AST pathway) (4/5 steps found)
• L-arginine degradation XIII (reductive Stickland reaction) (4/5 steps found)
• L-ornithine biosynthesis I (4/5 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• L-arginine degradation VI (arginase 2 pathway) (3/4 steps found)
• L-arginine degradation I (arginase pathway) (2/3 steps found)
• superpathway of arginine and polyamine biosynthesis (12/17 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• L-N^δ-acetylornithine biosynthesis (4/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.11 or 2.6.1.13 or 2.6.1.17 or 2.6.1.81

Protein Sequence (398 amino acids)

>GFF3745 N-acetylornithine aminotransferase (EC 2.6.1.11) (Sphingobium sp. HT1-2)
MSITPLMPVYPRCDVRPVRGEGCYLIGERGERYLDFASGIAVNLLGHGHPRLVKTIADQA
ATLMHISNLYGSPLGEEFAQKLVDNSFADTVFFTNSGAEAVECAIKTARRYHYANGQAHR
HKIISFDNAFHGRTLGTISATSQPKMRDGFEPLLPGFQVVPFNDLDAALAAIDDNTAGFL
LEPVQGEGGVTPATQAFLAGLRKACDEHGLLLILDEVQCGYARTGTFFAHEQYGVKPDIM
AVAKGIGAGFPLGACLATEEAAKGMVFGTHGSTYGGNPLAMAVGIAVLEEVLADGFLEQV
TAMGARLRSALEQMIPNHDDMFEDVRGMGLMLGVKMKDAYDARAFVGHLRDHHGFLSVSA
GQNVLRILPPLVIDESHIAECIEKISAGARSFADAKAA