Protein Info for GFF372 in Xanthobacter sp. DMC5

Annotation: Cobyric acid synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 484 PF13500: AAA_26" amino acids 3 to 229 (227 residues), 53 bits, see alignment E=6.3e-18 TIGR00313: cobyric acid synthase CobQ" amino acids 5 to 477 (473 residues), 415.4 bits, see alignment E=1.6e-128 PF01656: CbiA" amino acids 5 to 237 (233 residues), 72.8 bits, see alignment E=3.7e-24 PF07685: GATase_3" amino acids 254 to 437 (184 residues), 172.2 bits, see alignment E=1.6e-54

Best Hits

Swiss-Prot: 83% identical to COBQ_XANP2: Cobyric acid synthase (cobQ) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 83% identity to xau:Xaut_3778)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (484 amino acids)

>GFF372 Cobyric acid synthase (Xanthobacter sp. DMC5)
MARALMFQGTGSDVGKSLIVAGLARAFTLRGLKVRPFKPQNMSNNAAVTADGGEIGRAQA
LQARAARVRASVHMNPVLLKPQGETGAQVVVQGQVHGTAKAAAYQSLKPTLMPAVLDSFA
RLSGEADLVLVEGAGSASEVNLRAADIANMGFARAADVPVVLIGDIDRGGVIASLAGTKA
VIDPADAAMIRGFIVNRFRGDPALFASGMELIARLTGWDALGLVPHFPDAARLPAEDALA
LSAPPPPKAGARLRIAVPILPHVSNFDDLDPLDAEPGVGVRRIRPHESLPLDTDLVLMIG
SKATIADLTALKAGGLHHDILAFARRGGAVLGLCGGYQMLGQTIADPEGVEGEARIARGL
GLLDVHTVLTGEKRLEEVTGTAEGAPFLGYEMHMGATHGADCDRPFGHLADGRPEGARSA
SGLVAGTYVHGLFASDAFRAAMLGRLGGKGGGIAYEDGVEATLDALAAHLAAHLDLDRLL
TLAR