Protein Info for GFF3711 in Xanthobacter sp. DMC5

Annotation: Coenzyme PQQ synthesis protein B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 299 TIGR02108: coenzyme PQQ biosynthesis protein B" amino acids 2 to 299 (298 residues), 406.6 bits, see alignment E=2.9e-126 PF00753: Lactamase_B" amino acids 47 to 181 (135 residues), 28.2 bits, see alignment E=1.8e-10 PF12706: Lactamase_B_2" amino acids 51 to 266 (216 residues), 144.2 bits, see alignment E=4.2e-46

Best Hits

Swiss-Prot: 61% identical to PQQB_METC4: Coenzyme PQQ synthesis protein B (pqqB) from Methylobacterium extorquens (strain CM4 / NCIMB 13688)

KEGG orthology group: K06136, pyrroloquinoline quinone biosynthesis protein B (inferred from 82% identity to xau:Xaut_1802)

Predicted SEED Role

"Coenzyme PQQ synthesis protein B" in subsystem Coenzyme PQQ synthesis or Pyrroloquinoline Quinone biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (299 amino acids)

>GFF3711 Coenzyme PQQ synthesis protein B (Xanthobacter sp. DMC5)
MQVIVLGSAAGGGVPQWNCRCPVCQLAWKGDPRVTPRTQSSIAVSEDGASWVLLNASPDL
RAQIAATRALQPRVDGRDSPIRAVVLTNGDVDHIAGLLTLREQQAFEVYGTADTLALIEQ
NQVFDVVSKALVRREPVSFEVPFSPVPGLTMEFFTVPGKVPLWREDASLVIGEESGSTVG
VTITSAGSRLVYVPGCAAVTDALRQRISGADLLFFDGTLYRDDEMIAAGIGTKTGARMGH
LSMSGADGTVALLADLPVARRVFIHINNTNPALIDGSEEHRAVEAAGWTVARDGMEFSL