Protein Info for GFF3688 in Variovorax sp. SCN45

Annotation: ATP synthase epsilon chain (EC 3.6.3.14)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01216: ATP synthase F1, epsilon subunit
  • amino acids 4 to 132 (129 residues), 138.5 bits, E=6.4e-45
• PF02823: ATP-synt_DE_N
  • amino acids 5 to 84 (80 residues), 103.6 bits, E=4.5e-34
• PF00401: ATP-synt_DE
  • amino acids 89 to 131 (43 residues), 30.7 bits, E=2.8e-11

Best Hits

Swiss-Prot: 92% identical to ATPE_POLNA: ATP synthase epsilon chain (atpC) from Polaromonas naphthalenivorans (strain CJ2)

KEGG orthology group: K02114, F-type H+-transporting ATPase subunit epsilon [EC: 3.6.3.14] (inferred from 99% identity to vap:Vapar_4868)

MetaCyc: 53% identical to ATP synthase F1 complex subunit epsilon (Escherichia coli K-12 substr. MG1655)
ATPSYN-RXN [EC: 7.1.2.2]; RXN0-7041 [EC: 7.1.2.2]

Predicted SEED Role

"ATP synthase epsilon chain (EC 3.6.3.14)" in subsystem F0F1-type ATP synthase (EC 3.6.3.14)

MetaCyc Pathways

• ATP biosynthesis (1/1 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation
• Photosynthesis

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.14

Use Curated BLAST to search for 3.6.3.14 or 7.1.2.2

Protein Sequence (139 amino acids)

>GFF3688 ATP synthase epsilon chain (EC 3.6.3.14) (Variovorax sp. SCN45)
MAGTIHVDVVSAEESIFSGEAKFVALPGEAGELGIYPRHTPLITRIRPGAVRIEMADGAE
EFVFVAGGILEVQPNAVTVLSDTAIRGKDLDDEKANQAKAAAEEALKNAKSDIDIAMAQS
ELAVMAAQIAALRKYRQKK