Protein Info for GFF3638 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Pyridoxal kinase (EC 2.7.1.35)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00687: pyridoxal kinase
  • amino acids 1 to 285 (285 residues), 460.2 bits, E=1.4e-142
• PF08543: Phos_pyr_kin
  • amino acids 73 to 257 (185 residues), 62.8 bits, E=3.5e-21
• PF00294: PfkB
  • amino acids 132 to 248 (117 residues), 40.2 bits, E=2.7e-14

Best Hits

Swiss-Prot: 100% identical to PDXY_SALCH: Pyridoxal kinase PdxY (pdxY) from Salmonella choleraesuis (strain SC-B67)

KEGG orthology group: K00868, pyridoxine kinase [EC: 2.7.1.35] (inferred from 99% identity to seg:SG1668)

MetaCyc: 91% identical to pyridoxal kinase 2 (Escherichia coli K-12 substr. MG1655)
Pyridoxal kinase. [EC: 2.7.1.35]

Predicted SEED Role

"Pyridoxal kinase (EC 2.7.1.35)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 2.7.1.35)

MetaCyc Pathways

• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (11/12 steps found)
• pyridoxal 5'-phosphate salvage I (5/6 steps found)
• pyridoxal 5'-phosphate salvage II (plants) (6/9 steps found)
• 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II (4/8 steps found)

KEGG Metabolic Maps

• Vitamin B6 metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.35

Use Curated BLAST to search for 2.7.1.35

Protein Sequence (286 amino acids)

>GFF3638 Pyridoxal kinase (EC 2.7.1.35) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLT
EIVQGIADIGQLAHCDAVLSGYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEKG
CIVAPGVAEFHVRYALPASDIIAPNLIELEILSKHSVNNVDDAVQAARELIAQGPEIVLV
KHLARAGYSSERFEMLLVTAQEAWHISRPLVDFGSRQPVGVGDVTSGLLLVKLLQGATLQ
QALEHVTAAVYEIMIATKTMQEYELQVVAAQDRIANPEHYFSATRL