Protein Info for GFF3612 in Sphingobium sp. HT1-2

Annotation: 'GTP 3',8-cyclase (EC 4.1.99.22)' transl_table=11

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 335 TIGR02666: molybdenum cofactor biosynthesis protein A" amino acids 9 to 335 (327 residues), 358.6 bits, see alignment E=1.4e-111 PF04055: Radical_SAM" amino acids 22 to 184 (163 residues), 122.5 bits, see alignment E=3.1e-39 PF13353: Fer4_12" amino acids 25 to 129 (105 residues), 33.9 bits, see alignment E=5.4e-12 PF06463: Mob_synth_C" amino acids 190 to 314 (125 residues), 114.3 bits, see alignment E=5.9e-37

Best Hits

Swiss-Prot: 57% identical to MOAA_SINMW: GTP 3',8-cyclase (moaA) from Sinorhizobium medicae (strain WSM419)

KEGG orthology group: K03639, molybdenum cofactor biosynthesis protein (inferred from 82% identity to sch:Sphch_0517)

Predicted SEED Role

"Molybdenum cofactor biosynthesis protein MoaA" in subsystem Molybdenum cofactor biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (335 amino acids)

>GFF3612 'GTP 3',8-cyclase (EC 4.1.99.22)' transl_table=11 (Sphingobium sp. HT1-2)
MVDPAATSMTDGLGRRIDYLRISVTDRCDLRCRYCMAERMQFLPKNQVLTLEEIALLADL
FIARGVRRIRLTGGEPLVRRDIIDLIRRIARHLDTGLQELTLTTNGTRLADHAEALHDAG
VRRINVSLDSLQADRFAHITRGGDLTAVRRGLDAARAAGLTIKINMVALKDINADEILPM
LRWCDSQGFDLTLIETMPLGETGEDRTDHYLPLSHVAQEIDAHHALTPIAARTGGPARYH
DAEGLGIRLGLITPLTRNFCADCNRMRMTCEGKIYMCLGHDDHVDFKAALRSGGLAAVEP
LVDRALRRKPAAHDFRIGAGAPTAAVQRHMSVTGG