Protein Info for GFF3578 in Xanthobacter sp. DMC5

Annotation: Allantoinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00857: dihydroorotase, multifunctional complex type
  • amino acids 23 to 425 (403 residues), 322.2 bits, E=2.5e-100
• PF01979: Amidohydro_1
  • amino acids 54 to 420 (367 residues), 76.5 bits, E=2.4e-25
• PF07969: Amidohydro_3
  • amino acids 214 to 389 (176 residues), 32.5 bits, E=6.8e-12

Best Hits

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 92% identity to xau:Xaut_1415)

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• UMP biosynthesis II (6/6 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• UMP biosynthesis I (5/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.3

Use Curated BLAST to search for 3.5.2.3

Protein Sequence (446 amino acids)

>GFF3578 Allantoinase (Xanthobacter sp. DMC5)
MPVTFDLLLKGGAVATPAGIAVADIGVTGGRIRAIGDLSAASAGEVVDATGLHILPGVVD
TQVHFREPGLEQKEDLETGSRAAVMGGVTGVFEMPNTIPQTTNPSALEDKIARATARMHC
DFAFYVGGTHDNVKDLPELERLPGAAGIKVFIGSSTGSLLVPDDDGVRNILKVIRRRAAF
HCEDEPRLQERKGLRVPGDASSHPVWRDEIAALTATRRLVNLARETGARVHVLHVTSAEE
MDFLADARDVASVEVTPHHLTMAAPECYERLGTLAQMNPPVREARHRDGLWAAIANGVVD
VLGSDHAPHTLEEKSKPYPESPSGMTGVQTLVPLMLDHVAAGRLTLERFIDLTSAGPARL
FGIAGKGRIVVGYDADFTVVDLKRRATITNGWIASRAQWTPYDGKEVTGWPVGTFVRGRK
VMWEGELTGPSAGQPIRFLETLQPQG