Protein Info for PS417_18285 in Pseudomonas simiae WCS417

Annotation: multidrug transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1044 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 342 to 361 (20 residues), see Phobius details amino acids 368 to 390 (23 residues), see Phobius details amino acids 396 to 418 (23 residues), see Phobius details amino acids 439 to 461 (23 residues), see Phobius details amino acids 473 to 497 (25 residues), see Phobius details amino acids 542 to 564 (23 residues), see Phobius details amino acids 871 to 889 (19 residues), see Phobius details amino acids 896 to 916 (21 residues), see Phobius details amino acids 922 to 943 (22 residues), see Phobius details amino acids 971 to 991 (21 residues), see Phobius details amino acids 1002 to 1025 (24 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1040 (1040 residues), 1578.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1026 (1026 residues), 1270.5 bits, see alignment E=0 PF03176: MMPL" amino acids 332 to 537 (206 residues), 40.3 bits, see alignment E=2e-14

Best Hits

Swiss-Prot: 60% identical to ACRB_ECOLI: Multidrug efflux pump subunit AcrB (acrB) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 62% identity to ajs:Ajs_2837)

MetaCyc: 60% identical to multidrug efflux pump RND permease AcrB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-356; TRANS-RXN-357; TRANS-RXN-359; TRANS-RXN0-592

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UHX2 at UniProt or InterPro

Protein Sequence (1044 amino acids)

>PS417_18285 multidrug transporter (Pseudomonas simiae WCS417)
MAHFFIDRPIFAWVIAIVIMLGGSLSISQLPLEQYPDIAPPTVKISATYTGASAKTVEDS
VTQVIEQQMKGLDNLTYMSATSSSAGSASISLTFTAGTDPDVAQMQVQNKLQQAESRLPQ
SVQSEGLTVTKGGSDFLMIVALASDDPSVTGTQIGDYISTTLLDSISRIDGVGDVQTLGS
GYAMRIWLDPALLEKYALMPSDISSALEAQNTEVSAGQLGALPAIKGQQLNATISARSKL
QTVDEFRKVVVKSNSDGAVVLLGDVATLELGSESYDISTALNGKPAAAMGVQLAAGANAL
NVGKAVKAKLKEMEPFYPTEMQLKNVIAYDTTPFVSLSIEEVVKALGEAIVLVVLIMFLF
LQSLRATLIPAITVPVVLLGTFGVLALFGYSINTLTMFAMVLAIGLLVDDAIVVVENVER
LMGEGLSPVAATRQSMREISGALVGITLVLSAVFIPMAFFGGSTGIIYRQFSVTIVSAMV
LSVLVAMTLTPALCATLLKARNGKGHGAQHGFFGWFNRTFERASAGYERWVGVVLRRWGR
SLLLYGLVLVVMAVGYVSLATSFLPDEDQGILLAQIQLPVGATDSRTQAVIKQFEDYILQ
QPEVEAMISISGLGMGGNSQNTARAFIRLKDWSERGGSGQGAAAIAQRATLALSSIGDAD
AFVMQPPTVRGLGQSSGFDLQLKDLGGLGHDALVAAREQFLELARKDARLLGVRSNGLDD
APQLKVSIDDRKAGALSLSTSDINSTLATALGGTYVNDFLNQGRVKKVYVQGQASSRMQA
ADLDHWFVRNSNNEMVPFSSFASSTWGYGSPLLERYNGNASLEIVGDPAPGVSSGDAMAA
VEAIVRQLPQGIGYEWTGQSYQLRLSGSQAPLLYGISVLFVFLCLAALYESWSVPFSVIL
VVPLGVIGAVLATRVAGLSNDVYFQVGLLTTVGLAAKNAILIVEFAKHLQEQGSSVIDAT
LVAVRQRLRPILMTSLAFMFGVLPLALSTGAGSAGRQAIGTGVLGGMFSATVLGIFFVPL
FFVLIRGRFGRVRSANQSAPTGDA